LAPATINIB

(Tyrosine Kinase Inhibitor)

BRAND NAMES:
Tykerb,Tyverb
MECHANISM OF ACTION INDICATION ADVERSE
EFFECTS
It binds reversibly to the ATP- Metastatic Breast Diarrhea
binding site of the tyrosine kinase Cancer in Shortness of
part of the ErbB receptor thus
combination with breath
preventing phosphorylation of the
receptor causing activation of the cell Capecitabine in Dry cough
proliferation and survival pathways. patients whose Fast,irregular,pou
tumors overexpress nding heartbeat
HER2 and who have QT prolongation
received prior or torsade de
therapy including pointes
an Anthracycline, a Weakness
Taxane, and Swelling of the
Trastuzumab hands, feet,
ankles, or lower
legs
Rash
Lapatinib. (n.d.). Retrieved April 01, 2017, from https://www.drugbank.ca/drugs/DB01259
Goodman & Gilmans The Pharmacological Basis of THERAPEUTICS. Twelfth edition: pg 1731-1740
Lapatinib (Tyverb ). (n.d.). Retrieved April 01, 2017, from
http://www.macmillan.org.uk/cancerinformation/cancertreatment/treatmenttypes/biologicaltherapies/cancergrowthinhibitors/lapatinib.aspx