Professional Documents
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ENGINEERING (MENB403)
Topic 2 Radiation Environment
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Radiation Environment
Contents:
Radiation Detection and Units
Radiation in Everyday Life
Usages of
Radiation/Radioisotopes in
Medical and Industrial
Applications
Radiation Effects and Dose
Estimates
Radiation Protection and
Shielding
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Facts of Radiation
Radiation is a fact of life - all around us, all t
he time
Ionizing radiation
Neutrons
DISCOVERY OF X RAYS BY ROENTGEN (1895)
Wilhelm Conrad
Roentgen
DISCOVERY OF URANIUMS NATURAL RADIOACTIVITY
wR wT
Absorbed
Absorbed Equivalent
Equivalent Effective
Effective
Dose
Dose Dose
Dose Dose
Dose
(Gy)
(Gy) (Sv)
(Sv) (Sv)
(Sv)
Fluence
(cm
(cm-2-2))
Conversion
Conversion
Factor
Factor
(Sv
(Sv cm
cm22))
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Natural Background ANNUAL DOSE
mSv/year
Few people
In few areas ~100 VERY HIGH
Many people
In many areas TYPICALLY HIGH
~ 10
Majority of people
around the world AVERAGE
~ 2.4
MINIMUM
~1
nternational Safety Standards
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nternational Safety Standards
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RADIATION & RADIOISOTOPES APPLICATIONS
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IN THE BEGINNING
The science of atomic radiation, atomic ch
arge and nuclear fission was developed fro
m 1895 1945
Medical
Diagnostic, therapeutic, sterilization
Industry
Radiography, tracers, gauging radiation proces
sing
Food and agriculture
Food preservation, tracers, mutation
Research
Tracers
NUCLEAR TECHNOLOGY IN MEDICINE
RI in medicine are used either in liquid for
m (radiopharmaceuticals), for diagnosis an
d therapy or as solid sealed sources for the
rapy mainly for cancer. RI also find extern
al applications in in vitro diagnosis (immun
oassays)
RADIOPHARMACEUTICALS
RP are used for diagnostic imaging studies
The RI Tc-99m is used in more than 80% o
f the diagnostic imaging studies for assessi
ng the dynamic function of various organs
and localization of infections.
WHAT ARE RADIOPHARMACEUTICAL
S?
Chemical/biologi Radioisotope
cal (e.g. 99mTc, Iodine-131
(e.g. carrier tracer
MDP/antibody)
Radiopharmaceutical
(e.g. 99mTc-Antibody)
TYPES OF RADIOPHARMACEUTICALS
Prepared products
I-123 capsules
Ga-67 citrate
Tl-201 chloride
Xe-133 gas
Tc-99m pertechnetate
Kits for preparation of Tc-99m products
DTPA
MDP
MAG3
sestamibi
products requiring significant manipulation.
Cr-51 RBC's
Tc-99m RBC's
Tc-99m WBC's
In-111 WBC's,
In-111 Platelets
RADIOPHARMACEUTICAL KITS
Offers the convenience o
f on site preparation
What are kits?
MDP scan
(for bone scan) Na99mTc04 (for thyroid
- structure unknown scan)
- strong avidity to - similar charge/radius
hydroxyapatite ratio with iodine
crystals in bones
A) Graves disease; B) Thyroiditis;
C) Adenoma; D) Normal
Saw, Maung Maung, Cosmos 8.01 (2012):
(for myocardial perfusion (for myocardial perfusion scan)
scan) - lipophilic, cationic
- lipophilic, cationic - affinity to negative membrane
- potential drive diffusion potential
across of mitochondria of myocytes
sarcolemmal membrane
Octreoscan
Indium-111-Pentetreotide
(Octreoscan(R) - intense tracer
localization in the pancreatic
Zolle, Ilse, ed. Springer, mass (arrow head) with diffuse
2007. liver metastases.
NeoTect
No use of weapons-grad
e uranium
Starting material is stable
and non-radioactive
Little to no creation of nu
clear waste
Ease of operation
PET IN ONCOLOGY
PET in Cardiology
Addicts
Non-
addicts
F-DOPA labeled amino acid
used to detect dopamine
deficiency
Healthy Parkinson
s
Disease
In Alzheimers decreased metabolism can be detected
through a scan.
NEW CYCLOTRON PRODUCED RADIOISOTOPES FOR DIA
GNOSTIC AND THERAPY: DIAGNOSTIC
ors.
Critical Appx. %
Reacto
Location ity worldwide 99Mo
r
date production
NRU Chalk River, Canada 1957 40
Petten, the
HFR 1961 30
Netherlands
BR2 Mol, Belgium 1961 10
OSIRIS Saclay, France 1966 10
Pelindaba, South
SAFARI 1965 10
Africa
Two aging nuclear reactors (NRU and HFR), were shut down rep
eatedly for extended maintenance periods - culminating in a wor
ldwide shortage.
CYCLOTRON-PRODUCED TC-99M
Tc-99m can be produced directly in a cyclotron by b
ombarding a molybdenum-100 (Mo-100) target with
a proton beam.
100Mo (p,2n) 99mTc
19-24MeV proton energy
36 hours long
Feasibility studies to produce 99m Tc have been prove
n experimentally.
2,590 GBq (70 Ci) of 99mTc, two 6-h bombardments using
high-current medium-energy (500 A, 24 MeV) cyclotr
on
Head to head comparison between generator and
cyclotron produced Tc-99m yielded identical
images
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adiation Dose
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Radiation Dose
(cont.)
Radiation causes ionization and excitation of substances, including
human body.
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he Equivalent Dose
The definition of protection quantities is based on the mean absorbed
dose, DT,R, in an organ or tissue T, due to radiation of type R.
HT = (R) wRDT,R
where wR is the radiation weighting factor for radiation R.
These wR values are based on experimental data for the relative
biological effectiveness (RBE) of various types of radiations at low
doses, on biophysical considerations and on judgements.
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he Effective Dose
The effective dose can be represented as,
E = (T) wTHT,
where wT is the the tissue weighting factor for radiation R and HT
is equivalent dose.
Bone-marrow (red), Colon, Lung, Stomach, Breast, Remainder Tissues* 0.12 0.72
(Nominal wT applied to the average dose to 14 tissues)
Gonads 0.08 0.08
Bladder, Oesophagus, Liver, Thyroid 0.04 0.16
Bone surface, Brain, Salivary glands, Skin 0.01 0.04
* Remainder Tissues (14 in total): Adrenals, Extrathoracic (ET) region, Gall bladder,
Heart, Kidneys, Lymphatic nodes, Muscle, Oral mucosa, Pancreas, Prostate, Small
intestine, Spleen, Thymus, Uterus/cervix.
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The Effective Dose
(cont.)
The body related protection quantities (equivalent dose (HT) and
effective dose (E)) can not be applied directly in radiation
monitoring as they are not directly measurable.
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DOSE LIMITS
ln
2
71
Gamma-ray Source
Isotope Half-life Energies (keV)
Cobalt-57 270 days 122.1
Cobalt-60 5.27 years 1173.2, 1332.5
Sodium-22 2.6 years 511.0, 1274.5
Technetium 99m 6.01 hours 140
Beta-ray Source
Isotope Half-life Energies (keV)
Strontium-90 28.5 years 546.0
Alpha-particle Source
Isotope Half-life Energies (keV)
Polonium 210 138 days 5304.5
B: 511.6, 1173.2
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For example, Cesium-137 has its half-life of 30.1 years.
cataract
cancer &leukemia
Probabilitic effects
(assuming, without Thresho
Genetic influence
genetic disorder
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Basic Concept of Radiation Safety
obabilitic effects
suming, without Threshold)
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The shorter operating (treating) radiation- work, the less the
internal exposure of radiation.
So, you must make enough plans about work contents, a procedure
beforehand and do a simulation, and it is necessary to finish
radiation-work as possible in a short time.
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Appropriate shielding materials.
Youd better to perform "the radiation shielding" as much as possible near
source.
Pb, W, Fe or other
Paper heavy materials
Energy response
Proportional characteristics of radiation energy and the height
of output-wave
of the radiation.
High energy-resolution.
Timing response
High-speed response; short dead-time, rapid collecting of
electric charge.
Detection efficiency
The relationship between amount of incident radiation &
amount of output-pulse.
Price 84
Energy response
Depends on;
Energy-resolution
Depends on;
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Radiation Detector
online detector
off-line detector
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WIDELY USED DOSIMETERS
Effective
Effective Dose
Dose Doses
Doses in
in the
the area
area Survey
Survey contamination
contamination
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Semiconductor
Detector
rge is generated in Conduction Band, by Radiation Energy.
Energy of radiation
depleted layer
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Various Semiconductor Detector
Semiconduc Ionization Electron Hole Operating
Band Gap
tor Energy mobility mobility Temp.
(eV)
(eV) (cm2/V/s) (cm2/V/s)
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Scintillation Counter Detector
Energy resolution is not good, but detection efficiency is higher than
HP Ge detector.
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Thank You
Courtesy:
Yoshinobu IZUMI
Research Institute of Nuclear EngineerinG
University of Fukui
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