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and healing.
Onset of inflammation there is edema and
INF-
Stimulation of endothelial cells by C5a,
phagocytosis
Bacteria are coated with complement components
phagocytosis.
Antigen presenting cells such as
Peripheral Dendritic cells
(langerhans,macrophages,B cells) are
abundant in gingival cells, high titre of
serum IGg .
phagocytosis
Entrapment of the bacterial cell into
membrane delimnated structure known as the
phagosome.
cathepsin G.
,elastase, cathepsin G.
Tetracycline also inactivates MMPs and have
GCF.--bactericidal
Elastase degrades a wide range of molecules
production
TNF- is primarily produced by Th1 subset of
Activation of IL-1production
Induction of prostaglandin .
proteinases
stimulant of osteoclast
proliferation,
differentiation, and
activation
TNF- have same
effects on osteoclasts
but less potent
5/15/17 Dr Saif Khan 47
Prostaglandins
Arachidonic metabolite generated by
loss in Periodontitis
5/15/17 Dr Saif Khan 51
Connective tissue alteration: Healing Process
in Periodontitis
The chronic immune system plays an important
2. Angiogenesis
3. Fibrogenesis
response
and healing
IL-1 and IL- are indirectly involved in inducing