Ganguly, K., & Carmena, J. M.

(2009), PLoS Biology, 7(7)

A&C II
Anastasia Mukhina
15.05.2017 Emergence of a Stable Cortical Map for Neuroprosthetic Control
Can neural representation for prosthetic control become consolidated and remain stable over time?

2 macaque monkeys
Shuffled decoder:
Center-out reaching task
Recordings in M1 and PMd Non-biomimetic version of the initial decoder (unrelated Conclusions
to arm movements)
Results: Long-term usage of
Manual Control stage:
neuroprosthetic devices creates a
-Cursor controlled by arm movements -Initial significant drop in performance
consolidated neural
-Recorded brain activity for arm movement control -Accurate performance with initial decoder maintained representation of motor control,
Brain Control stage: Two decoders:
-Accurate prosthetic control achieved after 3 days that is:
- Cursor controlled via Brain Machine Interface Two decoders: 1.Stable across time
-19 consecutive days Biomimetic, both used each day. 2.Readily recalled
Two distinct prosthetic motor
Well-learnt decoder and new, 3.Resistant to interference
also trained on MC data.
Results: maps
Results:
emerged for each of the
-BC skill was transferred from one day to another Multiple cortical maps for
-Stable performance after day 8 - two decoders
Stabilized performance for neuroprosthetic control could be
both decoders after 4 days successfully learnt and used
-Changes in neuronal activity map tracked improvements in task performance
- Two distinct prosthetic motor independently.
maps Even a non-biomimetic decoder
Stable task performance was strongly associated with the consolidation
of a neuronal ensemble activation pattern. can be successfully used for
Once one cortical map becomes consolidated, prosthetic control.
Once neural representation for neuroprosthetic control is consolidated,
the entire ensemble map appears to be actively involved in BC. a second map could be learned, stored and
used interchangeably.

Neuroprosthetic devices could eventually be controlled through the effortless recall of motor memory in a manner
that mimics natural skill acquisition and motor control.