ADVERSE EFFECTS

OF THERAPY
DIABETES MELLITUS
Benefits of efforts directed toward
glycemic control must be balanced
against the risks of treatment.
 Side Effects of Intensive
Treatment
Increased frequency of serious
hypogylcemia
Weight gain
Increased economic costs
Greater demands on patient
MOST SERIOUS COMPLICATION

HYPOGYLCEMIA
 WEIGHT GAIN
Insulin, insulin secretagogues,
thiazolidinediones
Metformin, a-glucosidase
inhibitors, GLP-1 receptor
agonists & DPP-IV inhibitors
FDA
Requires information about the
cardiovascular safety profile as part
of its evaluation of new treatment
for type 2 DM.