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Helminthes
Parasitic worms are highly differentiated
multicellular organisms with complex life cycles.
Most alternate between sexual reproduction in
the definitive host and asexual multiplication in
an intermediary host or vector.
Depending on the species, humans may harbor
adult worms (e.g. Ascaris lumbricoides),
immature forms (e.g. Toxocara canis), or asexual
larval forms (e.g. Echinococcus species).
Once adult worms take up residence in humans,
they generate eggs or larvae destined for the next
phase of the cycle.
This is significant in that helminthic disease is
usually proportionate to the number of infecting
organisms.
Moreover, pathology related to helminth
infections is usually due to inflammatory
responses to the eggs or larvae rather than to the
adult forms (e.g. the robust granulomatous
inflammation in schistosomiasis).
Strongyloides stercoralis is an exception in that
larvae can become infectious in the gut and cause
overwhelming autoinfection in
immunocompromised hosts.
Key Points
Diseases caused by microbes involve interplay of
microbial virulence and host responses.
Infectious diseases are due to organisms ranging in size
from viruses to parasitic worms. It may be contiguous
in origin, results from nosocomial organism or be due
to endogenous microflora.
Infectious agents can directly cause cell death or
dysfunction by binding to or by entering host cells.
Infectious diseases can be transmitted through o Direct
contact o Respiratory droplets o Faecal-oral routes o
Blood-borne contact o Sexual transmission o Vertical
transmission o Insect/arthropod vectors
Injury may be due to local or systemic release of
bacterial products, including endotoxins,
exotoxins, or superantigens.
Pathogens can induce immune responses that
cause tissue damage.
Absence of an immune response may reduce the
damage induced by some infections, conversely,
immunocompromise can allow uncontrolled
expansion of opportunistic agents or of
microorganisms that can directly cause injury.
Evaluation
What are the causes of infectious disease?
What are the factors making one susceptible
to infections?
What is pathogenicity?
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