METABOLISM

By
Dr. drh. Heru Nurcahyo, M.Kes
Biology Dept. Math and
Natural Science Faculty, YSU
 Bahan Keterkaitan
Makanan PERAN
PENCERNAAN
MAKANAN
Pencernaan dengan
Secara mekanis,
kimiawi dan metabolisme
mikrobiotis

Sari-sari Metabolis
absorpsi
makanan me
seluler
KONSEP METABOLISME
 DIGESTION
VS
METABOLISM
CONCEPTS
Transport glukosa
melewati membran
sel secara difusi
terfasilitasi
 VARIOUS
PATHWAYS OF
METABOLISM
 JALUR
METABOLISME
 SKEMA
STRUKTUR
MITOKONDRIA
TRANSPORT
ELEKTRON
SALURAN
HIDROGEN
 Asam amino
untuk biosintesis
protein
Fig. 15-CO, p.670
Energy input Energy output
Metabolic Internal work Thermal energy
Food energy pool (heat)
in body
External work

Energy storage

Fig. 15-1, p.671

Table 15-1, p.672
Fig. 15-2, p.673
Fig. 15-3a, p.674
Fig. 15-3b, p.674
Fig. 15-3c, p.674
Fig. 15-4a, p.676
Fig. 15-4b, p.676
Fig. 15-4c, p.676
Fig. 15-4d, p.676
Fig. 15-5a, p.679
 Paraventricular N.

Mammillary N.

Arcuate N.

Supraoptic N.

Fig. 15-5b, p.679

Fig. 15-6, p.680
Internal heat
production

Core temperature

Heat input Total body Heat output

heat content

Heatgain Heatloss

External environment

Fig. 15-11, p.686

 Direction of arrows denotes direction of heat transfer

Snowball Heating pad

1 2

Liquid
converted
to gaseous
Convection vapor
current

3 4
Fig. 15-12, p.687
Fig. 15-13, p.689
Fig. 15-14, p.689
Multi-chaperone complex Dissociated complex

hsp70
hsp90
HSF-1 monomer
HSF-1 monomer

hsp40
Thermal stress

hsps prevent
Folded
inappropriate interactions
protein
hsp90

Unfolded hsp70
protein
hsp40

HSF-1 trimer
HSF-1 trimerization
and phosphorylation
PPP PPP

HSE HSE
hsp70 genes

hsp40 hsp90 hsp mRNA

hsp70 Nucleus

Cytosol
Fig. 15-16a, p.693
Fig. 15-16b, p.693
Table 15-2, p.694
p.694
Fig. 15-17, p.695
Fig. 15-18a, p.696
 Artery

Anastomosing
vein

Venae comitantes

Fig. 15-18b, p.696

Fig. 15-19, p.697
 Sulzers Blood flow out
vein

Brown
fat

Heat from
nonshivering
thermogenesis

Blood flow in

Fig. 15-19a, p.697

 Hypothalamus

Food Cold

Thermogenin
Heat
Sympathetic Brown fat cell
nerve

Noradrenaline 3
Mitochondrion
Triglyceride UCP
H+

ADP
Respiratory
ATP chain
FFA

Fig. 15-19b, p.697

 Skin temperature Core temperature Fig. 15-20, p.700

Central thermoreceptors
Peripheral thermoreceptors
(In hypothalamus,
(In skin)
other areas of CNS, andabdominal organs)

Hypothalamic
thermoregulatory
integrating center

Behavioral Sympathetic Sympathetic

Motor neurons
adaptations nervous system nervous system

Skeletal muscles Skin blood vessels Sweat glands

Muscle tone, Skin vasoconstriction

Sweating
shivering and vasodilation

Control of
Control of Control of Control of
heat production
heat production heat loss heat loss
or heat loss
AKIBAT FATAL KESALAHAN PEMIMPIN