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Mechanisms in Atherosclerotic
Stroke
Intracranial Compared With
Extracranial and Anterior Compared
With Posterior Circulation Disease
Authors :
ICAS Asian
cerebral
atherosclerosis
ACA
PCA
Previous studies have addressed
the differences in risk factors
and stroke mechanisms between
ICAS and ECAS, but the results
are inconsistent
In Situ
Thrombo-
occlusion
Statistical Analysis
Pearson 2 test
Differences between continuous variables
were evaluated using the Student t test
The variables tested in logistic regression
models were those with P<0.1 by univariate
analysis
Statistical analyses were performed using SPSS
software for Windows (version 18.0; SPSS)
RESULT
Differences Between ICAS and ECAS
Patients
Multiple logistic regression analysis identified
age, male gender, and hyperlipidemia as
factors more prevalent in ECAS than in ICAS
Multiple regresion analysis showed that age,
MetS, and history of stroke were factors more
prevalent in multiple ICAS. However, there
were no factors differentiating single ECAS
from multiple ECAS.
Differences Between Anterior and
Posterior Circulation Disorders
Multiple logistic regression analysis revealed
hypertension and diabetes mellitus were
factors more prevalent in posterior circulation
diseases.
Multiple regression analysis showed that in
patients with anterior circulation diseases,
ECAS was more closely associated with age,
male gender , and hyperlipidemia, whereas in
patients with posterior circulation, only MetS
emerged to be more prevalent in ICAS than in
ECAS
Lesion regression was encountered in a
minority of lesions. A, Spontaneous
recanalization of the anterior cerebral artery is
demonstrated. This vessel has several areas of
stenosis. This same patient had a 70% distal
vertebral artery stenosis on initial study that
was occluded on the repeat study. The patient
did not report any symptoms of stroke or TIA.
B, A distal vertebral stenosis was noted on the
initial study in this patient with left subclavian
steal. The repeat study shows marked
regression of the stenosis and mild vessel
irregularity
Definition of primary end point on MRA. The
severely stenosed left middle cerebral artery
(MCA) (A) was nearly occluded in the follow-up
MRA (B); this was defined as progression. The
severely stenosed left MCA (C) in another case
improved to moderate stenosis (D); this was
defined as regression. Each stenotic segment is
marked with a circle.
Discussion
VALID
PENTING
DAPAT DITERAPKAN