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LIPOPROTEINS Function?
Involved in assembly, structure, function, and metabolism
CLASSIFICATION of lipoproteins.
Activate enzymes important in lipoprotein metabolism
and act as ligands for cell surface
receptors.
A breakdown of VLDL
will form IDL
APOLIPOPROTEINS
Apolipoproteins are
proteins that bind
lipids to form
lipoproteins.
They facilitate
lipoproteins to
transport lipids through
the lymphatic and
circulatory systems
APOLIPOPROTEINS
Because lipids are insoluble, apolipoproteins have detergent like
(amphipathic) properties, alongside phospholipids, can surround lipids,
creating a lipoprotein particle that is water soluble and can move
through the blood circulatory system.
Apolipoproteins also serve as enzyme cofactors, receptor ligands and
lipid transfer carriers that regulate the metabolism of lipoproteins and
their uptake in tissues.
APOLIPOPROTEINS
ENZYMES IN LIPID METABOLISM
FAT METABOLISM
1. Exogenous
2. Endogenous
3. Reverse cholesterol transport
Luminal Phase
Fat Solubilisation
Lipase Action
Absorption
Exocytosis
1. Exogenous source of lipid via
intestinal absorption.
In hyperlipidemia, it can
cause endothelial injury,
lipoproteins accumulate
within the intima, and
generate oxidised LDL and
cholesterol crystals. In
addition, Apo B (in the LDL)
that can no longer be
cleared, triggers
inflammation foam cells.
Atherosclerosis
REVERSE
CHOLESTEROL
TRANSPORT
1. Lipid poor Apo A1, from the
liver and immature HDL accepts
cellular cholesterol and
phospholipids via ABCA1.
Further Reading
Further Reading
CETP
High concentrations of chylomicron remnants or VLDL particles result in lower levels
of HDL cholesterol, due to cholesterol ester transfer protein (CETP) mediating a
process of exchange HDL/LDL to VLDL/chylomicrons.
TG
HDL Cholesterol VLDL
Phospholipids
Estyl
SUMMARY
REFERENCES
UpToDate
https://www-uptodate-com.ezproxy.lib.monash.edu.au/contents/lipoprotein-
classification-metabolism-and-role-in-
atherosclerosis?source=see_link§ionName=LIPOPROTEINS%20AND%20ATHERO
SCLEROSIS&anchor=H15#H16
Medscape
http://www.medscape.org/viewarticle/416521_2