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1
pH: log
[H+]
Body fluid pH
PK = 4.76
pH=pK :
(CH3 COOH) = (CH3COO-)
100%
CH3COOH
Adding H+
Buffer pK
Buffer Pairs Reaction Rate
system values
Or
HCO3-
HCO3-
24 mEq/L HCO3-
16 mEq/L
18 mEq/L
PCO2 PCO2
PCO2
40 mmHg 40 mmHg
30 mmHg
(1.2 mmol) (1.2 mmol)
(0.9 mmol)
Compensated
normal Uncompensated Metabolic acidosis
Metabolic acidosis Respiratory buffering response
Protein
Buffering
Both IC and EC
protein have
negative charges
and can serve as
buffer for H+, but
because most
protein are inside
cells, they are
primarily
intracellular
buffer system.
Renal Buffering
Met-acid N -N
Met-alk N -N
Res-acid N -N
Res-alk N -N
Cause of Metabolic acidosis
Increased Noncarbonic Bicarbonate Los
acids (elevated anion gap) (normal anion gap)
HCO3 H+
Serum pH
Resp Renal correction
Compensation
Increased acid titration
Hypervent