Professional Documents
Culture Documents
AGENTS
Suryadi Nattadiputra
Department of Pharmacology
Medical Faculty
Sriwijaya University
LEARNING OBJECTIVES
To know the definition of antibiotic
To know classification & mechanism of action of antimicrobial
To know factors that determine the susceptibility & resistance of
microorganisms to antibiotics
To know how bacterial can be resistant to antimicrobial agents
To know how to select an antibacterial agent
To know susceptibility test (disk diffusion test)
To know host factors that determine selection of antimicrobial agents
To understand therapy with combined antimicrobial agents
To know the prophylaxis of infection with antibiotics
To understand superinfection
To understand antibiotics misused
Definition: Antibiotics are substances produced
by various species of microorganisms (bacteria,
fungi, actinomyecetes) that suppress the
growth of other microorganisms and eventually
may destroy them.
Route of Administration :
- oral
- parenteral
Host factors :
- Host defense mechanisms
- Local factors
- Age
- Genetic factors
- Pregnancy
- Drug allergy
- Disorders of the nervous system
Therapy with combined antimicrobial agents
- For specifically defined situation
Misuse of antibiotics.
- Treatment of untreatable infections
- Therapy of fever of undetermined origin
- Improper dosage
- Inappropriate reliance on chemotherapy alone
- Lack of adequate bacteriological information