Professional Documents
Culture Documents
L.O.
We are learning about the different levels of protein
structure
Starter:
1. Complete the card sort activity on carbohydrates from
the previous lesson
Key words protein, amino acid, amino group, carboxyl group, R group, peptide
bond, primary, secondary, tertiary, quarternary, disulfide, ionic, hydrogen.
Peptides
Key words protein, amino acid, amino group, carboxyl group, R group,
peptide bond, primary, secondary, tertiary, quarternary, disulfide, ionic,
The structure of proteins
Amino Peptide
acids bond
Hydrogen
bonds form Hydroge
n bonds
- helix
Portion of polypeptide chain
Hydrogen
bonds form
Hydroge
n bonds
- pleated sheet
- pleated
sheet
Amorphou
- helices s regions
Tertiary structure
- The way in which a protein coils up
to form a precise three-dimensional
shape is its tertiary structure.
Forces responsible for the formation of tertiary structure:
Hydrogen bonds
Ionic bonds
Disulphide bonds
Hydrophobic interactions
between non-polar side
chains
Hydrogen bonds
Shared electrons spend longer at
bonds to these atoms, forming a slight
molecule negative charge
C
O- +H N bonds to
molecule
hydrogen
bond
bond to
molecule O Basic group
C H
Acidic group O- +H N
bond to
H molecule
Ionic
bond
CH2 SH HS CH2
CH2 S S CH2
disulphide
bond
Valine Phenylalanine
R group R group
CH(CH3)2 CH2
Non-polar
OH R group CH3 17
Polar R
group Histidine 18
+HN NH
Polar R
38
Non-polar group CH2 19
R group
37 CH3 HS CH2 20
36 35 34 33 32 31 30 29 28 27 26 25 24 23 22 21
24 HN Hydrogen
13
23 CH2 bonds
25 22
21 20 19 18 17 16 15 14
30 31 32 36 37 38
Quaternary structure
- Some proteins consist of more than one polypeptide
chain held together in a precise three-dimensional
structure
- Two or more polypeptide chains are held together
gives a proteins quaternary structure. They are held
together by the same type of forces responsible for
the formation of tertiary structures
- Quaternary structures can also involve the additional of
non-amino acid derived groups known as prosthetic
groups
These prosthetic groups can be formed
from metal ions, sugars, vitamins, methyl
groups, phosphate groups, etc..
Bonds in proteins
The 3D shape of a protein is maintained by several types of
bond, including:
hydrogen bonds: hydrophobic
involved in all levels of interactions:
structure. between non-polar
sections of the protein.
Quick quiz!
Key words protein, amino acid, amino group, carboxyl group, R group, peptide
bond, primary, secondary, tertiary, quarternary, disulfide, ionic, hydrogen.
Biuret test for proteins
Key words protein, amino acid, amino group, carboxyl group, R group, peptide
bond, primary, secondary, tertiary, quarternary, disulfide, ionic, hydrogen.
To know how polypeptides are made.
To understand how polypeptides are arranged.
To understand how to test for proteins.
Random plenary
generator.
Key words protein, amino acid, amino group, carboxyl group, R group,
peptide bond, primary, secondary, tertiary, quarternary, disulfide, ionic,