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Isoniazid
Dosage: 10-15 mg/kg orally once daily
(maximum 300 mg daily)
Hepatic toxicity increases with rifampin
Peripheral neuritis, mild CNS toxicity,
gastric upset
Rifampin
Dosage: 10-20 mg/kg orally once daily
(maximum 600 mg daily)
Side effects include rash; hepatitis;
jaundice; GI upset; orange coloring of
urine, tears, sweat
Rifampin can accelerate clearance of
PIs (except RTV) and NNRTIs
Pyrazinamide
Dosage: 20-40 mg/kg orally once daily
(maximum 2 g daily)
Hepatic toxicity, rash, arthralgia, GI upset
Ethambutol
Dosage: 15-25 mg/kg orally daily
(maximum 2.5 g daily)
Toxicity includes optic neuritis, rash, nausea