University Assistant, Physiopathology and Immunology Chair I, UMF “Carol Davila”, Pulmonary pysiology There are three aspects of pulmonary function: • Perfusion - relates to blood flow through pulmonary vessels.
• Diffusion - refers to movements of oxigen and carbon
dioxide across capillary membranes
• Ventilation - relates to air excenge between alveolar
spaces and the atmosphere. Pulmonary pysiology • In inspirations the alveolar pressure is lowered below atmospheric pressure, and air flow into the trachea, bronchi, bronchioles and alveoli. • Expiration is a passive act, the lung –thorax sistems recoil to their resting position and the alveolar pressure increases above atmospheric pressure, then the air flows out through the respiratory tract Spirometry • The spirometry determines the effectiveness of the various mechanical forces involved in lung and chest wall movement. • The value obtained provide quantitative information about the degree of obstruction to airflow or the degree of restriction of inspired air. • The tests determine the presence, nature and extent of pulmonary dysfunction caused by obstruction, restriction or both. The ventilotory defect is:
• obstructive – increase air way resistence
• restrictive – limitation in chest wall excursion, • mixed defect – the ventilation is altered by both of mechanism. Restrictive ventilatory impairments • chest wall disease – injuri, kyphoscoliosis, spondylitis, muscular dystrophy, • extratoracic conditions – obesity, peritonitis, pregnancy, • interstitial lung disease - fibrosis, sarcoidosis, • pleural disease –fibrotorax, pleural effusions • space-occuping lesions –tumor Obstructive ventilatory impairments • periferal airway disease – COPD, bronchitis, asthma • pulmonary parenchimal disease –emphysema, • upper airway disease – pharyngeal, tracheal and laryngeal tumors, foreign bodies, stenosis Mixed-defect ventilatory impairments • pulmonary congestion Major division of lung volumes spirometry Procedure • In the mornig of the investigation is contraindicaite to smoke, use bronchodilatator. • The pacient sit to the stool. • Place nose clips on the nose, and instruct the patient to breathe normally through a mounthpiece ( is a filter for bacterial or viral) • Ask the pacient to take a maximal inspirations and then forcibly and completely exhale into the spirometer • have the pacient repeat this maneuver a minimum of three times. • If the result is not normaly , you moust admistrate bronchodilators with a handheld nebuliser and repeat spirometry is indicate. Atentions!
• Spirometry is a patient effort –dependent test
• The pain and altered mental status is a
contraindications for spirometry Identifying errors in spirometry traces Hesitation Premature finish
Cough
Poor effort Premature finish and restart
Interpreting the results Obstructive Restrictive Mixed
FEV1/FVC% Decreased increased Decreased
Or normal
FVC Decreased Decreased Decreased
Or normal
FEV1 Decreased Decreased Decreased
Or normal the Normal flow volume curve Severe Airflow Obstruction Severe Restrictive Defect subpleural bleb - emphysema subpleural bleb - emphysema Bronchoprovocation
• Asymptomatic and normal PEF between attacks
• Symptoms < 1 time a week
• FEV1 –normal ( > 80 %)
• Metode – inhalator administration – etacolina- for bronchobstructionM – Ventolin - for bronhodilatation BODY PLETHYSMOGRAPHY • pletysmograph – It is a closed chamber with a fixed volume in which the subject breathes the gas in the plethysmograph. – Measurement the TLC, RV, RAW( airway resistence), TLco ( diffusion) Pulmonary diffusing capacity • Requires the use of a gas that is more soluble in blood than in lung tissue –carbon monoxide • The diffusing capacity is measure for the carbon monoxide and is converted to oxigen by multiplying by 1.23. • Is necessary to adjustment with hemoglobin Lung Diffusing Lung Volume Terminology