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ANSWERS TO ASSIGN

MARCH 9, 2017
1.

 CSS = RO DOSE = 300 MG/ 6 HRS = 50 MG/ HR


------------------ KE = 0.693/ 15 = 0.0462 HR
KE X VD
CSS = 50 MG/ HR X 0. 70
-------------------------------
0.0462 HR X 40 L
= 18.94 MG/ L
2

 CSS = RO DOSE = 300 MG/ 24 HRS = 12.5 MG/ HR


------------------ KE = 0.693/ 15 = 0.0462 HR
KE X VD
CSS = 12.5 MG/ HR X 0. 70
-------------------------------
0.0462 HR X 40 L
= 4.73 MG/ L
3.

CSS = RO DOSE = 300 MG/ 24 HRS = 50 MG/ HR


------------------ KE = 0.693/ 15 = 0.0462 HR
KE X VD
4.

CSS = RO DOSE = 600 MG/ 24 HRS = 25 MG/ HR


------------------ KE = 0.693/ 15 = 0.0462 HR
KE X VD
= 25 MG/ HR X 0.7
0.0462 HR X 40 L
= 9.47 = 9.5 MG/ L
5.

CSS = RO DOSE = 300 MG/ 12 HRS = 25 MG/ HR


------------------ KE = 0.693/ 15 = 0.0462 HR
KE X VD
= 25 MG/ HR X 0.7
0.0462 HR X 40 L
= 9.47 = 9.5 MG/ L
6.

 LBW = 50 kg + 2.3 kg for each inch over 5 ft ( 152.4 cm)


= 82.73 kg
 CLcr = (140 – age) x wt in kg
72 x Ccr
= (140- no age) x 82.73 kg
72 x 2.6 mg/ dL
= __________________
7a.

 Hepatic extraction ratio = fu X Cl int


QH + (fu X Cl int)
= 0.23 x 3,000 L/ hr
90 L/ hr + 0.23 x 3,000 L/ hr
= 690 L/ hr
780 L/ hr
= 0.88
7b.

 F= 1- ClH
= 1- 0.88
= 0.12
7c.

 CLH = QH X EH
= 1.5 L/MIN TO L/HR ( 90 L/ HR X 0.88)
= 79.2 L/ HR
7e.

 CL TOTAL= CL HEPATIC + CL RENAL


= 79.2 L/ HR + FU X GFR
= 79.2 L/ HR + (0.23 X 120 ML/ MIN OR 7.2 L/ HR)
= 80.86 L/ HR
7d.

FE = CL TOTAL /VD
= 80.86 L/HR/ 210L
= 0.385 = 0.38
7f.

 CPSS = S x KO
-----------------------------------
CL TOTAL
= 0.62 X 125 MG/ HR
--------------------------------
80.86 L/ HR
= 0.96 MG/ L
7g.

Hepatic extraction ratio = fu X Cl int (3,000 x 1.5)


QH + (fu X Cl int)
= 0.23 x 4,500 L/ hr
90 L/ hr + 0.23 x 4,500 L/ hr
= 1,035 L/ hr
1, 125 L/ hr
= 0.92
CLH = QH X EH
= 1.5 L/MIN TO L/HR ( 90 L/ HR X 0.92)
= 82.8 L/ HR
7h.

 F = 1- E
= 1- 0.92
= 0.08
7i.

 CLH = QH x EH
1.5 ml/ min  90 L/ hr X 0.17= 15.3  90 l/hr – 15.3 = 74.7 L/ HR
CLH = 74.7 L/HR X EH( 0.90)
CLH = 67.23 L/ HR

EH = fu X Cl int
QH + (fu X Cl int)
= 0.23 X 3000L/HR
74.7 L/HR +( 0.23 X 3000L/HR)
= 690L/ HR
764. 7 L/ HR
=0.90 L/ HR

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