Professional Documents
Culture Documents
INFECTION
Dan Gil Manauis
Mariz Kayl Reyes
Objectives
Primary or Recurrent
depends on whether the infection is occurring
for the first time or is a repeated event
Uncomplicated UTI
Catheterization
The longer the urinary catheter is in
place, the higher the risk for growth of
bacteria and an infection
Diagnosis
Urinalysis
Leukocyte Esterase Test
Gram Stain of Urine
Culture and Sensitivity
Diagnosis
Kidney and bladder Magnetic resonance
ultrasound imaging (MRI)
Voiding Radionuclide scan
cystourethrogram Urodynamics
Computerized Cystoscopy
tomography (CT) scan
Laboratory Result
Fosfomycin has good distribution into tissues, low Clinical cure rates may be slightly inferior
incidence of adverse events
Treatment Recommendations
Treatment Recommendations
A Case Study on Urinary
Tract Infection
Chief Complaint
“Over the past 24 hours, I’ve been
alternating between urinating frequently
to needing to urinate and not being able
to.”
History of Past Illness
J.M. is a 21 year old woman who
presents in to the University Clinic with
a 24 hour history of dysuria, frequency
and urgency. She also complains of
constipation. She denies sexually active.
Past Medical History
UTI 6 months ago
Bulimia; states that she has been
trying to eat better and is not
vomiting anymore.
Family History
Non-contributory
Social History
Non-smoker
Lives with her mother
Medication History
ALTERNATIVE TREATMENT:
Ciprofloxacin 250-500mg 1tab BID
for 3 days.
Pain Management in UTI
PHENAZOPYRIDINE
100-200mg by mouth after meals TID for
2 days.
Initial Drug Therapy
DRUG DOSAGE STRENGTH ROUTE FREQUENCY MOA
Ciprofloxacin 250-500mg 1tab Oral Twice a day for 3 days Inhibits relaxtion of
DNA; Inhibits DNA
Gyrase in susceptible
organisms; promotes
breakage of double-
stranded DNA.
Phenazopyridine 100-200mg Oral Thrice a day for 2 days Acts directly on urinary
tract mucosa when
excreted, to produce
local analgesic effect.
Initial Drug Therapy
DRUG INDICATION RELEVANT TO CASE MONITORING REQUIRED DESIRED THERAPEUTIC
OUTCOME
MECHANISM OF ACTION
Inactivates or alters bacterial ribosomal proteins and
other macromolecules that may interfere with
metabolism and cell wall synthesis.
NITROFURANTOIN
MECHANISM OF ACTION
Blocks bacterial cell wall synthesis by
inactivating enolpyruvyl transferase and also
reduces bacterial adherence to uroepithelial
cells.
FOSFOMYCIN
MECHANISM OF ACTION
Inhibits relaxtion of DNA; Inhibits DNA
Gyrase in susceptible organisms; promotes
breakage of double-stranded DNA.
CIPROFLOXACIN
Adverse Effects
Nausea
Abdominal pain
Diarrhea
Increase aminotransferase levels.
Vomiting
HA
Increase serum creatinine
Rash
restlesness
CIPROFLOXACIN Interactions
MECHANISM OF ACTION
Acts directly on urinary tract mucosa when
excreted, to produce local analgesic effect.
PHENAZOPYRIDINE
Prilocaine
Monitoring
Urinalysis is used as the method of monitoring
the effectiveness of the treatment with the
parameters of:
≤2-5 WBCs/hpf
≤2 RBCs/hpf
No Bacteria
Negative (-) Nitrite
Desired Therapeutic Outcome
Nitrofurantoin:
6 AM 6 PM
5AM 7AM 8AM 9AM 10AM 11AM 12PM 1PM 2PM 3PM 4PM 5PM 7PM 8PM
Drug Therapy Timeline
Ciprofloxacin:
6 AM 6 PM
5AM 7AM 8AM 9AM 10AM 11AM 12PM 1PM 2PM 3PM 4PM 5PM 7PM 8PM
Drug Therapy Timeline
PHENAZOPYRIDINE:
6 AM 2 PM
10 PM
5AM 7AM 8AM 9AM 10AM 11AM 12PM 1PM 2PM 3PM 4PM 5PM 6PM 7PM 8PM 9PM
Pharmacist Care Plan
Health Care Need Pharmaco- Recommen dation/ Monitoring
therapeutic Goal Measures