Belinda Rodriguez

Gerardo Venegas
Josue Zometa
 What is CMV
 CYTOMEGALOVIRUS (CMV) IS CLASSIFIED AS A MEMBER OF THE HERPES
FAMILY OF VIRUSES.
CMV IS A COMMON INFECTION THAT IS USUALLY HARMLESS.
ONCE CMV IS IN A PERSON'S BODY, IT STAYS THERE FOR LIFE.
USUALLY ASYMPTOMATIC
THOSE AT GREATEST RISK OF INFECTION ARE:
 FETUSES (CONGENITAL CMV)
 IMMUNOCOMPROMISED
Human Cytomegalovirus
Virion Structure
 Immunology & SeroMarkers
CMV SHOWS ALTERATIONS IN T LYMPHOCYTE, AN INCREASE IN THE NUMBER
OF CD8+ LYMPHOCYTES AND A DECREASE IN CD4+ LYMPHOCYTES.
PRIMARY INFECTION, TEMPORARY VIRUS SPECIFIC IGM ANTIBODY RESPONSE
AND EVENTUAL SEROCONVERSION TO PRODUCE (IGG) ANTIBODIES TO THE
VIRUS.
REACTIVATION OF LATENT INFECTION IN SEROPOSITIVE (IGG) INDIVIDUALS,
MAY BE ACCOMPANIED BY SIGNIFICANT INCREASES IN IGG ANTIBODIES TO
THE VIRUS, BUT ELICITS NO DETECTABLE IGM RESPONSE.
REINFECTION BY A STRAIN OF CMV DIFFERENT FROM THE ORIGINAL
INFECTING STRAIN. A SIGNIFICANT IGG ANTIBODY RESPONSE IS
DEMONSTRATED. IT IS NOT KNOWN WHETHER AN IGM RESPONSE OCCURS.
 Mode of transmission
ORAL
RESPIRATORY
VENEREAL
 Symptoms
MILD ILLNESS
SORE THROAT
FEVER
SWOLLEN GLANDS
FATIGUE
CHILLS
LYMPHADENOPATHY
SPLENOMEGALY
 Complications
INTESTINAL UNEXPLAINED FEVER

DIARRHEA NERVOUS SYSTEM

FEVER ENCEPHALITIS
ABDOMINAL PAIN
LUNG
INFLAMMATION OF YOUR
PNEUMONITIS
COLON
BLOOD IN STOOL NEW BORN
LIVER COMPLICATIONS
ABNORMAL FUNCTION
CMV Patients
 Diagnosis
CULTURE OF VIRUS
ISOLATION OF CMV FROM URINE OR OTHER BODY
FLUID (CSF, BLOOD, SALIVA) IN THE FIRST 21 DAYS
OF LIFE IS CONSIDERED PROOF OF CONGENITAL
INFECTION
CONVENTIONAL CELL CULTURE IS REGARDED AS
GOLD STANDARD BUT REQUIRES UP TO 4 WEEKS
TO PROVIDE RESULTS
PCR MAY BE USEFUL IN SELECTED CASES
ELISA TO DETERMINE IF ACUTE INFECTION, PRIOR
INFECTION OR PASSIVELY ACQUIRED MATERNAL
ANTIBODY IN AN INFANT IS PRESENT
CMV SEROLOGY
THE PRESENCE OF CMV IGG ANTIBODY TITERS FOR
CONGENITAL INFECTION
THE DETECTION OF IGM IS INDICATIVE OF PRIMARY
INFECTION ALTHOUGH IT MAY ALSO BE FOUND IN
IMMUNOCOMPROMISED PATIENTS WITH REACTIVATION
 Treatment
ANTIVIRAL MEDICATION
GANCICLOVIR TREATMENT
VALGANCICLOVIR (VALCYTE)
CYTOMEGALOVIRUS IMMUNE GLOBULIN INTRAVENOUS
*VACCINE RESEARCH – THE RESEARCH IS A LIVE
ATTENUATED VACCINE KNOWN AS THE TOWNE STRAIN
BUT THERE ARE CONCERNS ABOUT ADMINISTERING
LIVE VACCINE WHICH COULD BECOME LATENT AND
REACTIVATES
 Preventive methods
BLOOD SCREENING
LEUKOCYTE DEPLETION
BLOOD IRRADIATION
 Reference
ANDERSON B, SCHULKIN J, ROSS DS, ET AL. KNOWLEDGE AND PRACTICES OF
OBSTETRICIANS AND GYNECOLOGISTS REGARDING CYTOMEGALOVIRUS
INFECTION DURING PREGNANCY—UNITED STATES, 2007. MMWR. 2008.
MELNICK M, SEDGHIZADEH PP, ALLEN CM, JASKOLL T (10 NOVEMBER 2011).
"MELNICK M., SEDGHIZADEH P. S., ALLEN C. M., JASKOLL T.". EXPERIMENTAL
AND MOLECULAR PATHOLOGY 92 (1): 118–25.
GREDMARK-RUSS S, DZABIC M, RAHBAR A, WANHAINEN A, BJÖRCK M,
LARSSON E, MICHEL JB, SÖDERBERG-NAUCLÉR C. (2009). "ACTIVE
CYTOMEGALOVIRUS INFECTION IN AORTIC SMOOTH MUSCLE CELLS FROM
PATIENTS WITH ABDOMINAL AORTIC ANEURYSM.". J MOL MED. 87 (4): 347–56.