Review Questions

Questions
Week 1 lectures
1. All the
A. NK cells.
following cells are B. B lymphocytes.
considered part of C. monocytes.
innate (natural) D. neutrophils.
immunity EXCEPT:
1. All the
A. NK cells.
following cells are B. B lymphocytes.
considered part of C. monocytes.
innate (natural) D. neutrophils.
immunity EXCEPT:
2. Which of the following
cells that participate in cell-
mediated immunity are
antigen specific and directly
cytotoxic for target cells?
A. Macrophages
B. Th1 cells
C. Cytotoxic T cells
D. Natural killer cells
2. Which of the following
cells that participate in cell-
mediated immunity are
antigen specific and directly
cytotoxic for target cells?
A. Macrophages
B. Th1 cells
C. Cytotoxic T cells
D. Natural killer cells
 A. bacterial capsule is removed by
opsonin.
B. opsonin digests the bacterial cell
wall.
3. Phagocytes more
readily engulf C. opsonin induces the production of
lysosomal enzymes.
opsonin-treated
D. opsonin inhibits the ability of the
bacteria than bacteria to swim away from the
untreated bacteria phagocyte.
because the E. surface of phagocytes express
receptors for the Fc portion of IgG
and/or C3b.
 A. bacterial capsule is removed by
opsonin.
B. opsonin digests the bacterial cell
wall.
3. Phagocytes more
readily engulf C. opsonin induces the production of
lysosomal enzymes.
opsonin-treated
D. opsonin inhibits the ability of the
bacteria than bacteria to swim away from the
untreated bacteria phagocyte.
because the E. surface of phagocytes express
receptors for the Fc portion of IgG
and/or C3b.
 A. D and B
B. C1 and C2
4. Which of the C. C4b and C3b
following are D. C3a and C5a
anaphylotoxins? E. C8 and C9.
 A. D and B
B. C1 and C2
4. Which of the C. C4b and C3b
following are D. C3a and C5a
anaphylotoxins? E. C8 and C9.

5. If a patient suffers with an
increased susceptibility to
septicemias by Neisseria sp.,
but not other bacteria.
Which of the following
complement activities is
most likely deficient in this
patient?
A. Enhancing phagocytosis
B. Recruitment of neutrophils
C. Vasodilation
D. Formation of membrane attack
complex
E. Mast cell degranulation

5. If a patient suffers with an
increased susceptibility to
septicemias by Neisseria sp.,
but not other bacteria.
Which of the following
complement activities is
most likely deficient in this
patient?
A. Enhancing phagocytosis
B. Recruitment of neutrophils
C. Vasodilation
D. Formation of membrane attack
complex
E. Mast cell degranulation
 A. Enhances the phagocytosis of
bacteria by macrophages
6. The soluble fragment B. Increases edema and redness in a
produced by C3 skin abscess
convertase can directly C. Kill bacteria
participate in which of D. Lysis red cells in autoimmune
the following activities? hemolytic anemia
E. Remove soluble immune complexes
 A. Enhances the phagocytosis of
bacteria by macrophages
6. The soluble fragment B. Increases edema and redness in a
produced by C3 skin abscess
convertase can directly C. Kill bacteria
participate in which of D. Lysis red cells in autoimmune
the following activities? hemolytic anemia
E. Remove soluble immune complexes
 A. C1q
7. Neutrophils B. C3b
are attracted C. C5a

to an infected D. Factor D
E. IgM
area by
 A. C1q
7. Neutrophils B. C3b
are attracted C. C5a

to an infected D. Factor D
E. IgM
area by
8. All of the A. they are constituents that increase
rapidly in response to infection.
following are
B. they are used to diagnose a specific
characteristic of disease.
acute-phase C. they enhance phagocytosis.
reactants D. they limit destruction of host tissue.

EXCEPT:
8. All of the A. they are constituents that increase
rapidly in response to infection.
following are
B. they are used to diagnose a specific
characteristic of disease.
acute-phase C. they enhance phagocytosis.
reactants D. they limit destruction of host tissue.

EXCEPT:
Questions
Week 2 lectures
9. Which of the A. F(ab)2
B. Fab
following has C. IgA
ten antigen D. IgG
binding sites? E. IgM
9. Which of the A. F(ab)2
B. Fab
following has C. IgA
ten antigen D. IgG
binding sites? E. IgM
 A. Antibody-dependent cell-mediated
cytotoxicity
10. Which of the
B. Complement activation
following biological C. Binding of allergen specific
functions is antibody to mast cells
independent of D. Neutralization
isotype of the E. Opsonization
antibody?
 A. Antibody-dependent cell-mediated
cytotoxicity
10. Which of the
B. Complement activation
following biological C. Binding of allergen specific
functions is antibody to mast cells
independent of D. Neutralization
isotype of the E. Opsonization
antibody?
11. A deficiency in A. IgA
which of the follow B. IgD
antibody classes can C. IgE
result in increase
susceptibility to D. IgG
respiratory infections? E. IgM
11. A deficiency in A. IgA
which of the follow B. IgD
antibody classes can C. IgE
result in increase
susceptibility to D. IgG
respiratory infections? E. IgM
 A. IgA
12. Which class of
B. IgD
antibody protects C. IgE
a newborn child D. IgG
from infections? E. IgM
 A. IgA
12. Which class of
B. IgD
antibody protects C. IgE
a newborn child D. IgG
from infections? E. IgM
13. Which option A. They are recognized by helper T cells.
B. They are found on all nucleated cells.
best describes
C. They combine with exogenous
MHC class I antigen.
antigens? D. They are coded for on chromosome 9.
13. Which option A. They are recognized by helper T cells.
B. They are found on all nucleated cells.
best describes
C. They combine with exogenous
MHC class I antigen.
antigens? D. They are coded for on chromosome 9.
14. MHC class I A. CD4+ T cells
antigens are B. CD8+ T cells
recognized by which C. B cells
of the following cells? D. Macrophages
E. NK cells
14. MHC class I A. CD4+ T cells
antigens are B. CD8+ T cells
recognized by which C. B cells
of the following cells? D. Macrophages
E. NK cells
 A. Fas
15. Which of B. TNF-alpha
the following C. CD4
D. CD8
binds to HLA-A E. CD28
 A. Fas
15. Which of B. TNF-alpha
the following C. CD4
D. CD8
binds to HLA-A E. CD28
 A. neutrophils.
16. Antigen can B. dendritic cells.
be presented to C. plasma cells.
naïve T cells by D. platelets.
E. red blood cells.
 A. neutrophils.
16. Antigen can B. dendritic cells.
be presented to C. plasma cells.
naïve T cells by D. platelets.
E. red blood cells.
 A. are primarily derived from
endocytosed exogenous molecules
B. are most often synthesized in the
cytoplasm
17. Peptides that C. cannot be recognized by a specific T
bind MHC class I cell receptor
molecules D. are always of microbial origin
E. are never processed by the immune
system
 A. are primarily derived from
endocytosed exogenous molecules
B. are most often synthesized in the
cytoplasm
17. Peptides that C. cannot be recognized by a specific T
bind MHC class I cell receptor
molecules D. are always of microbial origin
E. are never processed by the immune
system
18. A processed
antigen first A. nucleus.
encounters and binds B. endoplasmic reticulum.
to class I MHC C. endosomal compartment.
molecules in the: D. membrane surface.
18. A processed
antigen first A. nucleus.
encounters and binds B. endoplasmic reticulum.
to class I MHC C. endosomal compartment.
molecules in the: D. membrane surface.
A. By secreting TGF-b
B. By secreting IL-2
C. By activating dendritic cells
D. By expressing B7
E. By presenting antigenic peptides on
MHC class I
A. By secreting TGF-b
B. By secreting IL-2
C. By activating dendritic cells
D. By expressing B7
E. By presenting antigenic peptides on
MHC class I
20. Granzymes A. Phagocytosis
activate which of B. Apoptosis
the following in a C. Cytokine secretion
target cell? D. Complement activation
20. Granzymes A. Phagocytosis
activate which of B. Apoptosis
the following in a C. Cytokine secretion
target cell? D. Complement activation