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Lecture 7: CANNABIS I
Dr. Mark Haselgrove
Overview of the lecture
(1) Introduction
Background
History of Marijuana
Many uses:
Found in all parts of the plant, but concentrated in the sticky resin
secreted the flowing tops of ♀ plants.
Introduction
Background to Cannabis
Hashish (“Solid”)
- Prepared from resin
- Potency varies with concentration
Jacques-Joseph Mareau: Physician founded the “club of the hashish eaters” in Paris
Notable eaters: Victor Hugo, Alexendre Dumas
Introduction
History of Cannabis
Pharmacology of Cannabis
Typical Joint contains approximately 0.5 – 1g of cannabis
Agonist = THC
Antagonist = SR 141716
Acute Behavioural and Physiological effects
Behavioural effects: Iversen (2000)
Agurell et al (1986)
Driving
Marsicano et al (2002)
Valjent & Maldonado (2000) – Conditioned place preference with THC in mice
Email: Mark.Haselgrove@nottingham.ac.uk