How to treat the baby born from the mother

with HbsAg (+)?

P • Baby born from mother with HbsAg (+)

I • Hepatitis B vaccine

C • HBIg and hepatitis B vaccine

O • Effectiveness
CRITICAL APPRAISAL

4
VALIDITY

Is it stated clearly why systematic review should be done ?

• Yes.
• It showed clearly in introduction that study was to evaluate the effectiveness of
vaccine alone compared with combined immunization (HBIG and vaccine) of
infants born to mother with HBsAg+/HBeAg -
Were the studies validated ?
•Yes
•The studies validated using Jadad score

5
Are there inclusion criteria for the studies and the way of searching
and selecting the studies ?
• Yes

6
Is each study result consistent ?
• Yes.

7
Importance

Are the result of systematic review clinically important and

influence to change treatment in patient ?

• Yes.

10
 applicability

Are our patients simillar to the patient in this study?

• Yes.

Are the diagnosis tool available, affordable, and acceptable to patient ?

• Yes.

11
Level of evidence

Important

Valid Applicable

LoE
1B
12