1.

Below is a Virulence Factors of

Treponema pallidum, except...
A. Outer membrane proteins not promote
adherence
B. Hyaluronidase may facilitate perivascular
infiltration
C. Antiphagocytic coating of fibronectin
D. Tissue destruction and lesions are primarily
result of host’s immune response
(immunopathology)
2.Which is the characteristic of
spirochete...
A. Gram-positive
B. Extremely thick and can be very long
C. No endoflagella
D. Outer sheath encloses axial fibrils
3. A 20-year-old woman presents with a 2-cm
ulcer on her labia
majora. The lesion has a raised border and is
relatively painless.
What is the most likely pathogen?
A. Neisseria gonorrhoeae infection
B. papilloma virus infection
C. adenovirus infection
D. Troponema pallidum infection
4. A 47-year-old man presents with slowly progressive arthritis
in his knees. He enjoys hiking in the coastal areas of Northern
California, where the prevalence of Borrelia burgdorferi
in the Ixodes ticks is known to be 1–3% (considered low). The
patient is concerned about Lyme disease. He never noticed a
tick on his body and did not see an expanding red rash. The
result of an EIA for Lyme borreliosis is positive. What should
be done now?
(A) A biopsy specimen of the synovium of a knee joint should
be examined for Borrelia burgdorferi.
(B) The patient should be given an antibiotic to treat Lyme
disease.
(C) PCR on the patient’s plasma should be done to detect
Borrelia burgdorferi.
(D) A serum specimen should be submitted for immunoblot
assay to detect antibodies reactive with Borrelia burgdorferi
antigens
5. Dark-field microscopy may be used to diagnose spirochetes
in which of the following scenarios?
A. To detect spirochetes in the cerebrospinal fluid in a patient
with tertiary syphilis
B. To detect spirochetes in a suspicious lesion in the oral cavity
in a patient with secondary syphilis
C. To detect spirochetes in the urine of a patient with
suspected
leptospirosis
D. To detect spirochetes in the blood of a
6.
7.
8.
9. Streptobacillus moniliformis is a cause of
rat-bite fever. What other pathogen can also
cause rat-bite fever?
A.Treponema pallidum subspecies pertenue
B.Leptospira interrogans
C. Borrelia recurrentis
D. Spirillum minor
E. Brachyspira aalborg
10. Reverse sequence testing for the diagnosis of
syphilis...

A. Involves screening with a high-throughput EIA or

CIA
assay followed by confirmation using a
nontreponemal test
B. May be associated with a high level of false-
positive results
C. May be more sensitive than the traditional
algorithm in
detecting early disease
D. Is replacing the traditional algorithm in many
laboratories
E. All of the above