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Genus Coronavirus
CoV
&
Genus Torovirus
Coronaviridae
CORONAVIRUSES
The genome
- SS linear
non segmented
+ve sense RNA
- the largest
among RNA
viruses.
The family coronaviridae is
composed of two genera:
• Genus Coronaviruses
• Genus Torovirus:
– widespread in horses & cattle
– associated with gastroenteritis.
Genus Coronavirus
• First isolated in chicken in 1937
• Helical nucleocapsids.
A Crown-like Appearance
when viewed by EM
• Respiratory tract
• GI in infants
Relationship to human
infections
- Based on serologic studies,
coronaviruses cause respiratory tract
infections and pneumonia in humans.
• deletion mutations
gp II
(OC43)
gp III
SARS CoV
NO HUMAN
strains
Clinical picture & epidemiology
• Direct Detection
• Isolation
• Serology
Laboratory Diagnosis of
1. coronaviruses
DIRECT DETECTION:
• Antigen detection in cells of respiratory
secretions by IF or ELISA
ISOLATION:
• CoV are difficult to grow in CC.
- PASSIVE HAEMAGGLUTINATION
TEST
- ELISA
Laboratory diagnosis of
Gastroenteritis caused by
toroviruses
• Ag detection
• NA detection
SARS
SEVERE ACUTE RESPIRATORY
SYNDROME
SARS
• No vaccine
YET STOPPING THE
SPREAD OF INFECTION
WAS POSSIBLE
THROUGH
EFFECTIVE CONTROL
MEASURES
Control Measures
1. Isolation of patients
4. Hand Hygiene
Co- evolution
&
pathogenicity
Majority of corona viruses
cause
asymptomatic infection in their natural
hosts
reflecting
CO- EVOLUTION
of
HOST AND PATHOGEN
WHY SARS INFCTION
IN HUMANS IS Fulminant
This is attributed to
9. Important Latency < 50% of URTI Mutability & high high frequency
oncogenic frequency of of:
feature genetic
potential in deletion mutations
animals reassortment high frequency of
recombination
during replication
10. VACCINE
- Available -
-
4 families of 1ry Respiratory viruses
DNA RNA viruses
Adeno Rhino Orthomyx Corona
o
11. THREAT
LATENCY No
Epidemic &
potential
Potential
repetition of
pandemics infections
Threat similar to SARS
12.
50% Seasonal URT 15%
A. Respiratory diseases 5%:
Infections B. Eye infections:
C. Gastrointestinal disease:
& to 30%
D. OTHER DISEASES: of
Diarreaha
URT epidemic
- Acute haemorrhagic cystitis
Immuno-compromised
patients manifestations
are: influenza SARS
-Pneumonia
-hepatitis
-gastroenteritis