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Alternative names:
· Quartan malaria
· Falciparum malaria
· Blackwater fever
· Tertian malaria
A vector-borne infectious
disease caused by protozoan
parasites.
It is widespread in tropical and
subtropical regions
A bite from an infective female
Anopheles mosquito.
P.ovale.
P.malaria
Female Anopheles are:
The highly mobile microgametes will seek out and fuse with
a macrogamete. Within 12-24 hours the resulting zygote
develops into an ookinete. The ookinete is a motile invasive
stage which will transverse both the peritrophic matrix and
the midgut epithelium of the mosquito.
Sporogony. After reaching the extracellular space between
the epithelial cells and the basal lamina, the ookinete
develops into an oocyst. The oocysts undergo an asexual
replication, called sporogony, which culminates in the
production of several thousand sporozoites. This generally
takes 10-28 days depending on species and temperature.
Upon maturation the oocyst ruptures and releases the
sporozoites which cross the basal lamina into the hemocoel
(body cavity) of the mosquito.
Exoerythrocytic schizogony and
prepatent and incubation periods
P.
falciparu P. vivax P. ovale P. malariae
m
Prepatent
period 6-9 8-12 10-14 15-18
(days)
Incubatio
n period 7-14 12-17 16-18 18-40
(days)
Merozoite
maturatio 5-7 6-8 9 12-16
n (days)
Merozoite
s 40,000 10,000 15,000 2000
produced
• P. falciparum P. vivax P. ovale P. malariae
Hypnozoite -- + + --
Size of RBC normal normal normal normal
Parasite size 1/3 1/3 1/3 1/6
Multi parasite -- -- + --
Schffnrs duts -- -- + --
*Trophzoite:
Size of RBC normal enlarge enlarge normal
Parasite size 67% 100% 67% 100%
Parasite shape ameboid band ameboid compact
Suffner duts -- + + --
Maure duts + -- -- --
not seen in
P.B
malaria pigment
• P. falciparum P. vivax P. ovale P. malariae
Schizont :
size of RBC normal enlarge enlarge normal
Parasite size 67% 100% 67% 100%
Suffner duts -- + + --
# of merozoite 16-24 12-24 6-12 6-12(rostte s
not seen inP.B hpe)
Gamitosite:
Size of RBC crecent shape enlarge enlarge normal
Parasite size hall cell 100% 67% 100%
Age of cell any young young old
Disease malegnant benign benign benign
Signs & symptoms:
Blood examination:
Thick and thin blood film
Other tests:
CBC:
-Lukopenia
-Thrombocytobenia
-Esinophilia
-monocytosis
Quntitative buffy coat techniqe
Urinalysis
Increase ESR
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