PREPARATION 13

CALCIUM HYDROXIDE TOPICAL SOLUTION

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Solution
 Liquid preparation that contain
one or several soluble chemical
substance dissolve in suitable
solvent or mixture of mutual
miscible liquids

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 2 Components
 Solute
 One that is being dissolved

 Solvent
 one that dissolves

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Method of Preparation
1. Simple Solution
 prepared by dissolving the
solute in a suitable solvent
 Examples: NaCl solution, Strong
Iodine Solution

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Method of Preparation
2. Solutions by Chemical Reaction
 prepared by reacting two or
more solute with each other in a
suitable solvent
 Examples: Aluminum subacetate
solution, Magnesium citrate
solution, Sulfurated lime solution
By: Nelson T. Tubon
 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Method of Preparation
3. Solution by Distillation
 if the solute is a volatile oil

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Method of Preparation
4. Solution by Extraction
 Drug or pharmaceutical
necessities of vegetable or
animal origin
 Also called extractives

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

Methods of Extraction
 Maceration
 Percolation
 Digestion
 Infusion
 Decoction

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Category
 Topical Solution

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Synonyms
 Lime water

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Description of Final Product

 Clear, colorless solution with
an alkaline taste

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Use/s
 employed with other ingredients
in dermatological solution and
lotion
 as protector in lotion preparation
and an emulsifying agent

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Formulation
Ingredients OA CA

Calcium Hydroxide 3g

Purified water, qs ad 1000 mL 30 mL

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Computations

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Procedure
 Slake CaO (addition of water with the
liberation of heat to form a crumbly material in
mortar/beaker) covered with watch glass
Xg 0.09 g
 CaO + H2O  Ca(OH)2 + CO2  CaCO3
 MW 56g/n MW 74g/n

 xg : 56g/n:: 0.09g: 74g/n X= 0.07 g CaO

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Procedure
 Let stand for 5 minutes
 Add cold water and agitate for 1
hour to dissolve completely the CaO
 Filter collect only the supernatant
liquid.

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Procedure
 Add sufficient amount of cold
water up to the brim of the
container (no bubbles inside)
 A clear, colorless solution should
be achieved

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Label
 Red Label

 Container
 30 mL flint bottle

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Remarks
 The method preparation was simple
method
 Undissolved portion is not suitable for
preparation of additional quantity of
Ca(OH)2 soln. to ensure saturated
soln.
 Bottle should be filled up to the brim

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Remarks
 The solution should be stored in well-
filled, tightly stoppered containers
to deter the absorption of CO2 and
should be kept in a cool place to
maintain an adequate concentration of
dissolved solute.

By: Nelson T. Tubon

 PREPARATION 13
CALCIUM HYDROXIDE TOPICAL SOLUTION

 Remarks
 The solution is categorized as an
astringent.
 For this purpose it is generally
employed in combination with
other ingredients in dermatologic
solutions and lotions to be
applied.
By: Nelson T. Tubon
 PREPARATION 14
STRONG IODINE SOLUTION

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Category
 Topical Solution

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Synonyms
 Lugol’s solution
 Iodine Potassium Iodide
 Liquor iodi
 Aqueous Iodine Solution

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Description of Final Product

 A liquid with a deep brown
color and odor of iodine

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Use/s
 treatment of thyrotoxicosis
 antigoiterogenic
Germicidal and fungicidal
 antiseptic
 keratolytic

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Formulation
Ingredients OA CA

Iodine 50 g

KI 100 g

Purified water, qs ad 1000 mL

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Computations

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Procedure
 Dissolve KI in 3mL of water
 Add iodine to the mixture
 Add sufficient amount of water

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION

 Label
 Red Label

 Container
 30 mL amber bottle

By: Nelson T. Tubon

 PREPARATION 14
STRONG IODINE SOLUTION
 Remarks
 The method of preparation
used was simple solution
 In weighing the iodine crystals,
use porcelain spatula instead of
stainless because it reacts with
metal
 KI is used as solubilizing agent
By: Nelson T. Tubon
 PREPARATION 15
MAGNESIUM CITRATE

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Category
 Saline Cathartic

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE
 Synonyms
 Citrate
 Citrate of magnesia
 Magnessi citralis
 Lemonada purgante

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Description of Final Product

 It is a colorless to slightly
yellow, clear effervescent liquid
having a sweet acidulous taste
and a lemon flavor.

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Use/s
 saline cathartic

By: Nelson T. Tubon

PREPARATION 15
MAGNESIUM CITRATE

 Formulation
Ingredients OA CA

MgCO3 15 g

Anhydrous Citric acid 27.4 g

Syrup 60 mL

Talc 5 .0 g

Lemon oil 0.1 mL

KHC03 2.5 g

Purified water qs ad 350.0 mL 50 mL

 PREPARATION 15
MAGNESIUM CITRATE

 Computations

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Procedure
 Calibrate the bottle first (Mark the
level of 50mL distilled water)
 Dissolve citric acid in 21 mL water
 Mix (MgCO3)4 . Mg(OH)2 . 5H2O in
14 mL of water (another container)

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Procedure
 Mix (MgCO3)4 . Mg(OH)2 . 5H2O solution
with citric acid. (2 & 3) Stir until it is totally
dissolved
 (MgCO3)4 . Mg(OH)2 . 5H2O 
Magnesium Carbonate

C6H8O7  Mg3(C6H5O7) + 4CO2 + 11 H2O

Citric acid Magnesium Citrate

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Procedure
 Add syrup as a sweetening agent
and heat mixture to boiling (1-2
minutes)

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Procedure
 Mix lemon oil with talc
 Mix 6 and 5
 Filter the preparation while hot
into the sterilized and calibrated
bottle

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Procedure
 Add water until it becomes 50 mL
 Stopper using cotton. Let it cool in
running water
 Add KHCO3

 3KHCO3 + C6H8O7  K3C6H5O7 + 3CO2 + 3H2O

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Procedure

 Stopper with cork right away to

trap the gas. Let the bottle lie down
to wet and expand the cork.

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE

 Label
 white Label

 Container
 120 mL wide mouth flint bottle

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE
 Remarks
 The method of preparation
used was chemical reaction
 Sterilizing the bottle is done to
prevent the growth of
microorganism

By: Nelson T. Tubon

 PREPARATION 15
MAGNESIUM CITRATE
 Remarks
 Magnesium citrate soln. has always been a
troublesome because it has a tendency to
deposit a crystalline solid upon standing. This is
due to the formation of some almost insoluble
normal Mg citrate.
 The cause of the problem has largely attributed
to the indefinite composition of the official
MgCO3 which by definition is a basic hydrated
MgCO3 or a normal hydrated MgCO3.
(equation on p. 351 – Ansel).
By: Nelson T. Tubon
 PREPARATION 15
MAGNESIUM CITRATE
 Remarks
 The solution provides an excellent medium for
the growth of molds, and any mold spores
present during the manufacture of the solution
must be killed it the preparation is to remain
stable.
 for this reason: during the preparation  liquid
is heated to boiling (prior to carbonation); boiled
water is employed to bring the solution to its
proper volume; boiling water is used to rinse the
final container; final solution maybe sterilized
 Sterilize the bottle  to prevent contamination
By: Nelson T. Tubon
 PREPARATION 15
MAGNESIUM CITRATE
 Remarks
 Mg citrate solution is stored in a
cold place, preferably in a
refrigerator, keeping the bottle on its
side so the cork or rubber liner of the
cap is kept moist or swollen, thereby
maintaining the airtight seal between
the cap and the bottle

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Category
 Solution

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION
 Synonyms
Sodium Hypochlorite Solution

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Description of Final Product

 It is clear, light yellow solution
with the characteristic odor of
chlorine

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Use/s
 disinfectant
 antiseptic

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Formulation
Ingredients OA CA

Chlorox 5.25% 95 mL

Sodium Bicarbonate 27.4 g

Clear Tap water, qs ad 946 mL

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Computations

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Procedure
 Measure 30 mL of tap water
 Boil for 15 minutes in a water
bath. (The container must be
half closed)
 Add 0.1 g of NaHCO3

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Procedure
 Add 3 mL of bleach
 Place solution in a sterile container.
Close the lid tightly and cover the
entire container with aluminum foil to
protect from light

By: Nelson T. Tubon

 PREPARATION 15
DAKIN’S SOLUTION

 Label
 red Label

 Container
 sterile narrow mouth amber
bottle covered with aluminum
foil
By: Nelson T. Tubon
 PREPARATION 15
DAKIN’S SOLUTION
 Remarks
 The expiry date of the solution is
30 days after it has been
compounded
 The solution must be discarded
48 hours after it has been opened
 It must be stored at room
temperature
By: Nelson T. Tubon