Professional Documents
Culture Documents
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SEM Uncontrolled division of Breast cancer cells.
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Image: Annie Cavanagh 2006
HALLMARKS OF CANCER: ADAPTATIONS TO EVADE DEATH
• Nutrient source
– Glucose
– Amino Acids
– Oxygen
• Growth factors
• Structural support
– Extracellular Matrix
• Cell-Cell interactions
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• Non-small lung carcinoma: The two drugs, MLN128 and CB-839, individually
target the metabolism of key nutrients glucose and glutamine, respectively,
prohibiting the cancer from switching metabolic gears between glucose (a simple
sugar) and glutamine (an amino acid) to tap vital sources of energy. This switch
enables the cancer cells to adapt their metabolism and evade treatments. (Milica
Momcilovic et.al, 2018)
• It is possible that dual inhibition of both Ldh activity and glutamine uptake or
glutaminase could potentially starve tumors by circumventing their metabolic
flexibility, and this will be the focus of effort going forward. (A. Flores
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et.al.,2019)
METABOLIC TARGETS OF CANCER STEM CELLS.