Professional Documents
Culture Documents
• AETIOLOGY : UNKNOWN
• High-risk factor :
- Neurofibromatosis ( Von
Recklinghausen`s disease)
- Previous radiation therapy
- Long-lasting lymphoedema
Pathological appearance
• Originate from all mesenchymal tissues ( fat, muscular, connective
tissue, vessels, peripheral nerves, tendon and synovial
No : no regional metastases
N1 : positive regional lymphnode metastases
M0 : No distant metastases
M1 : Positive distant metastases
G1,2,3,4 (well,moderate,poorly,undiffer)
Stage 1A : G1-2, T1a or T1b ,N0,M0 ( low grade, small, superficial ,deep)
Stage IB : G 1-2, T2a , No,MO (low grade, large,superficial,
Stage IIA : G!-2, T2b, No,MO ( low grade,large,deep
Stage IIB : G3-4, T1-b,NO,MO ( high grade,small superf, or deep)
Stage IIC : G3-4, T2a, No,MO ( high grade, large, superficial tumor
Stage III : G3-4, T2b, No,Mo ( high grade, large, deep tumor)
Stage IV : any G,Any T,No,Ni,Mo,Mi (any meta lymphnode,distant metastases)
Treatment of STS
• Local treatment : standart therapy
- Wide excision ( compartment procedure,
amputation, safety margin 2 cm )
-Radiotherapy
• Systemic treatment : adjuvant therapy
Chemotherapy adjuvant (cyclophosphamide,
ifosphamid, adriamycin, dacarbacin,
vincristin, taxane, Growth factor /VEGF
Prognosis of STS
• Prognostic factors :
- Type of tumor
- Grade of malignancy
- Size of tumor
- Location
- Metastases
- Age of patient
- Recurrence