Applications of Non-smart

Hydrogels in Drug Delivery

System

Kinesh Patel & Neelam Patel

Department of Pharmaceutics and Pharmaceutical
Technology
 Introduction
- Diffusion controlled Drug Delivery
(1) Polymer matrix
Water-insoluble
Polymer matrices

time

(2) Reservoir system

Water-insoluble
Polymer membrane

time
Hydrogel Nanoparticles1

Cationic hydrogel nanoparticles for

DNA deivery
◦ E.g. of polymers used
 Poly(ethylene glycol)
 2-hydroxyethylacrylate
 2-acryloxythyle trimethylamonium
Affinity-Based Drug Delivery2
Photopolymerizable Hydrogels Made from
Polymer-Conjugated Albumin for Affinity-
Based Drug Delivery
The development of a hybrid hydrogel
composed of albumin conjugated to
poly(ethylene glycol) (PEG) for drug
delivery applications where controlled
release is accomplished using the natural
affinity of the drugs to the serum albumin.
◦ E.g., Naproxen, Warfarin
 Affinity-Based Drug Delivery cont…

Fickian diffusion model provided strong

evidence that hydrogels containing mono-
PEGylated albumin exhibited sub-diffusive
drug release properties based on the affinity
of the drug to the tethered protein.
 Hydrogel Pessary3
Drugs can be loaded successfully into a
hydrogel pessary vaginal drug delivery
system for treatment of pre-term labour and
endometriosis
◦ Polymer used:
 Cross-linked polyurethane
◦ Drugs:
 Terbutaline sulfate,
 Salbutaol sulphate
 Ritodrine hydrochloride
 CDDS
Biodegradable hydrogel functions as
reservoir for the controlled delivery of
soluble bioactive factors, including growth
factors, cytokines, DNAs and therapeutics
(e.g. stem cells)
Polymers:
◦ Poly(vinyl-alcohol)
◦ Chitosan
 Extracel™ Hydrogel
The inventors have now developed an in situ-
crosslinked, modified gelatin, multi-functional
hydrogel for use as a scaffold for damaged
tissues.
Extracel™ provides the basic scaffold for 3-D
cell growth.
Cells can be encapsulated during crosslinking,
where they attach and grow within the
hydrogel matrix, or they can be plated on top
of the hydrogel for pseudo 3-D growth.
Extracel™ Hydrogel Applications cont…
The following cells have been cultured in
Extracel™:
Primary Cells
◦ human tracheal scar fibroblasts
◦ human and rat primary hepatocytes
◦ human dermal fibroblasts
◦ human mesenchymal stem cells
CellLines
Cancer-Cell Lines
Extracel™ Hydrogel Applications cont…

Human dermal fibroblasts grown on the

surface of an Extracel™ hydrogel.
PVA-gelatin hydrogels4
PVA-gelatin membranes were made by
esterification of the hydroxyl group of
PVA with the carboxyl group of gelatin.
The hydrogel developed was found to be
superabsorbent, to be hemocompatible
with human blood, and to allow diffusion
of drug.
E.g., drug delivery systems and moist
wound dressings.
 References
1. De Gao, Hao Xu, Martin A. Philbert, and Raoul
Kopelman, Nano Lett. 2008 October; 8(10): 3320–
3324
2. Liat Oss-Ronen, Dror Seliktar, Advanced
Engineering materials, 12(1-2),2010:B45-B52
3. Labastie, M. et al., J. Pharm. Biomed. Analysis. 10
(10-12) (1992) 1105-1108
4. Pal K, Banthia AK, Majumdar DK. Preparation
and Characterization of Polyvinyl Alcohol–Gelatin
Hydrogel Membranes for Biomedical
Applications. AAPS PharmSciTech.
2007; 8(1): Article 21.