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hyperacidity
AZL & ZR
Dep. Farmakologi & Terapeutik,
Fakultas Kedokteran
Universitas Sumatera Utara
Oktober 2008, KBK Block GIS
Acid-Related Pathophysiology
The stomach secretes:
• Hydrochloric acid (HCl)
• Bicarbonate
• Pepsinogen
– Pepsin breaks down proteins (proteolytic)
• Intrinsic factor
• Mucus
– Provide a protective mucous coat
– Protect against self-digestion by HCl
• Prostaglandins
Drugs used in dyspepsia
• Anti-acid agents • Prokinetic Agents
– Antacids / Alginates – Cisapride - withdrawn
– H2A’s – Metoclopramide /
– PPI’s Domperidone