Professional Documents
Culture Documents
NCM 106
Etiology
Contd
D. Implementation c. Complementary Therapies a. Pharmacological - Botanical agents Therapy - Nutritional Supplements b. Nutrition and Diet - Mind-Body modalities Therapy Energy healing - ACS Dietary - Spiritual approaches Guidelines to Prevent Cancer - Miscellaneous Therapies Specific Disease Conditions
Cells
Divided into intervals or steps represented by G for gap, M for mitosis and S synthesis Go
G1
G2
G0 Phase
Resting state
G1 Phase
RNA and CHON synthesis proliferation activity- short G1
Signals beginning of G1 phase when triggered activity- lengthened G1 by immediate Restriction point committed to environment S phase
Initiate DNA synthesis
S Phase
Synthesis of both DNA G2 Phase and CHON of new chromosomes occurs Biochemical processes and some RNA synthesis 6-8 hrs. interval Only small percentage Little is known, lasts few hours of cells fraction () predictor M Phase of long-term survival
Actual cell division Daughter cells Less than an hour few hours
CANCER
A disease whereby cells mutate into abnormal cells that proliferate abnormally
Malignant Neoplasm
CANCER
Tumor Neoplasm
Tumor
Neoplasm
abnormal tissue mass with no useful purpose benign can be fatal if near vital tube or organ malignant invades other tissues and may metastasize distant organs Oncology deals with diagnosis, treatment, and study of cancer Carcinogen- any substance or agent that tends to produce a cancer Carcinogenesis - process of cancer development
Incidence
affects every age group, most deaths occur in people older than 65 years old highest incidence: prostate CA
Highest in males:
prostate CA lung CA colorectal CA
Highest in females
breast CA lung CA colorectal CA
ETIOLOGY
Viruses
Genetic & Familial Idiopathic
Chemicals
Physical Agents
Hormonal
Carcinogenesis
Dietary
Carcinogens
Drugs Viruses Tobacco Overwhelm the Alcohol
immune system
Carcinogens
Foods, preservatives
Nitrites (meat) talc (gum) nitrosomines (rubber nipples) mold in grains, nuts, cheese
Carcinogens
Genetics Physical Agents
Radiation Physical Exposure to Oncogene carcinogens irritation/trauma
Overuse of body organ
Hormones
Estrogen
Cell changes
PATHOGENESIS OF CANCER
Cellular Transformation Theory
Cell transformation due to exposure
EFFECTS OF CANCER
Disruption of Function
FATIGUE + sleep disturbances, treatment, nutritional status PHYSICAL STRESS
Pain
+ 60-80 % of cases + from pressure, obstruction, invasion, stretching of visceral surfaces, tissue destruction, inflammation Ex: stretched liver RUQ dull pain compressed nerve endings 1st priority Tx control pain rapidly 2nd priority prevent recurrence
Anorexia-Cachexia
most common causes of death
Cachexia- severe form of malnutrition leading to wasting, extensive loss of adipose tissue, emaciation multi-factorial process of hormones and proinflammatory cytokines, TNF, interferons decrease food intake
Hematologic Alterations
chronic bleeding, Fe-defficiency, therapy, blood-forming organs malignancy
cytokine-release suppresses erythropoietin in BM r- HuEPO (recomb. Human erythropoietin) improve myelosuppression
Infection
most significant complications and death fall in granulocytes and lymphocytes
high-risk reduced immunologic functions debility immunosuppression from radiotherapy and chemotherapy
Paraneoplastic Syndromes
effects of hormones and other substances released by tissue 10% of malignancy may be earliest symptoms of unknown cancer represent life-threatening problems mimic progression and interfere with treatment
American Cancer Societys Seven Warning Signs of Cancer Change in bowel or bladder habits A sore that does not heal Unusual bleeding or discharge Thickening or lump in breast or elsewhere Indigestion or difficulty swallowing Obvious change in wart or mole Nagging cough or hoarseness
ASSESSMENT
RISK FACTORS
ASSESSMENT
Diet & Obesity
Xenobiotics transported to blood & react with molecules causing cell damage
Defenses: - detoxification enzymes - antioxidant systems
ASSESSMENT
Occupation
Lung CA- Exposure to asbestos Bladder CA dyes, rubber, paint, benzidines Leukemia benzol inhalation by shoemakers, rubber cement workers and explosives
ASSESSMENT
Socio-economic status Stress Sun exposure/Radiation
ASSESSMENT
Tobacco Use
Alcohol
Drugs