IPT, Vit C and QOL

2nd Annual Riordan IVC and Cancer Symposium October 8 & 9, 2010

Bradford S. Weeks, M.D.

www.weeksmd.com md@weeksmd.com

GOALS for this Presentation

1) understand the role of insulin in potentiating chemotherapeutic benefits 2) understand the theoretical and practical aspects of Corrective Cancer Care (including Insulin Potentiation Therapy) 3) begin to incorporate side-effect free chemotherapy in your clinical practice.
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Disclaimer: no commercial interest or conflict of interest declared

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A Common Understanding of a DOG

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RORY
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New Puppy Syndrome

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Rory really enjoying a car ride with Amelia

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Corrective Medicine and Psychiatry

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Thanks and Congratulations!

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Abram Hoffer

Hugh Riordan

David Horrobin

Rudolf Steiner Otto Wolff

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Tenzin Choedrak

"A physician once told me that nothing arouses so much bitter enmity and heated arguments among his colleagues, as the subject of cancer. This may be due to the guilty recollections of cancer victims expiring who might have been saved; or of the memories of patients pronounced hopelessly ill who recovered under the treatment of a 'quack,' or who miraculously lived without further treatment. Possibly these guilt reactions and the remorse over exhausting the money of patients and their relatives in futile cancer treatments, account for some of these psychological manifestations which are expressed in hostility and attack." Nat Morris (written in 1958)
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Even Bill Gates took some risks in life

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Its not so important whether you win or lose but rather, how you play the game. My goal is to improve the quality and quantity of your life.
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The Role of Hope

There are no incurable illnesses, only incurable people.

Paracelsus
(1433-1541)

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Insulin Potentiation Therapy for the Treatment of

(people with)

Cancer Part 1: The History and Rationale

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On July 27, 1921, Canadian scientists Frederick Banting and Charles Best first isolated insulin and within a year, the first human sufferers of diabetes were receiving insulin treatments. Lilly began manufacturing large doses of purified insulin in November 1922. In 1926, Donato Perez Garcia had 10 units of insulin injected intravenously."

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The Development of the IPT Concept

Donato Perez Garcia, Sr., MD (1896 - 1971) first conceived of the therapy in Mexico City in 1926 and named it Cellular Therapy to Change the Biophysical Biochemical Constants of the Blood. Treated infectious illnesses: malaria, syphilis and poliomyelitis before focusing on cancer. His son, Donato Perez Garcia y Bellon, MD (1930 - 2000) and and grandson - Donato Perez Garcia, Jr., MD (1957 - ) followed in his footsteps. Steven Ayre, MD learned about the therapy in 1975 and became the teacher of American doctors. Bradford Weeks, M.D. learned IPT in 2001 from Dr. Ayre and is a certified clinical instructor in IPT for doctors wishing to learn this methodology.
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From the book, Terapia Celular or Cellular Cancer Therapy through Modification of Blood Physico-Chemical Constants or Donatian Therapy - written by Donato I & II:
According to Terapia Celullar, an animal study with dogs was done in 1930 to test absorption of anti-syphilis drugs, namely mercury and Neosalvarsan Prior to this, the doctor had given himself intramuscular injections.
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A human study with neurosyphillis patients was conducted in Austin State Hospital in 1937, the results of which are discussed in a letter by Dr. Garcia dated September 1937. On April 10, 1944, TIME magazine published an article on Dr. Garcia's "Insulin Shock Therapy," in which a visit to the San Diego Naval Hospital is discussed, where Dr. Garcia treated malaria and rheumatic fever patients. Wed like him to come back and do it again.
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According to the timeline written by Dr. Donato,

"January 1946 - First breast cancer patient successfully treated using IPT."
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Find a cure before I grow boobs!

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Conventional Chemotherapy Pros: Powerful drugs Effective at killing cancer

Cons:
Powerful drugs Effective at killing patients while killing cancer cells Cost (average oncologist mark up = 400%) Effectiveness rate = 2.1% (!!!)
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Problems with Conventional Chemotherapy

1) Adequate intra-cellular concentrations requires high dose, systemic administration of these drugs. 2) Lack of tissue specificity for drugs.

3) Consequence: Multiple tissue and organ toxicity (side-effects).

4) Note the tragic and little reported facts that 1) chemotherapy and radiation do NOT kill stem cells and 2) 99% of the cells in a cancerous tumor are NON-cancerous
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FACT: ~ 2% of all cancers respond to chemotherapy (!!!??) FACT: Conventional Chemotherapy hurts more than it helps.

OPINION: The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA . . . chemotherapy only makes a minor contribution to cancer survival. To justify the continued funding and availability of drugs used in cytotoxic chemotherapy, a rigorous evaluation of the costeffectiveness and impact on quality of life is urgently required.
Morgan G, Ward R, Barton M. in his article: The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. See Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.)
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Why Do Cancer Cells Resist Chemotherapy?

1. 2. 3. 4. 5. 6. resistant cells survive and reproduce survival of the fittest; cancer cells mutate and replicate gene amplification: hundreds of copies of genes which produce chemoinactivating proteins (inc. MDR gene expression). P-glycoprotein pump which pumps drug out of cells (inc. MDR expression). cancer cells inactivate the pump which brings the drugs into the cells (e.g. decreased expression folate transporter with MTX). cancer cells learn to repair DNA damage caused by some chemo drugs (inc. nucleoside excision repair with alkylating agents and platinum drugs; inc. O alkyl-guanine alkyl transferase with nitrosureas, procarbazine, and temozolamide). cancer cells learn to inactivate chemo drugs or decrease their activation (decreased folypolyglutamyl synthetase with MTX or decreased deoxycytidine kinase with cytosine arabinoside, fludarabine phosphate, and cladrabine). increased detoxification (increased glutathione or GSH tranferase)

7.

8.

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What would be the Elements of an Ideal Solution to this Chemotherapy Dilemma?

1) To develop a method of differentiating the cancer cell
population from the normal cell population. 2) To deliver lowered doses of drug more specifically into this differentiated cancer cell population. 3) To maintain and /or enhance chemotherapys cellkilling effectiveness in cancer cells. 4) To reduce / avoid chemo side effects in normal cells.
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Which box are you thinking outside of?

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Insulin Potentiation Therapy

Utilizes Insulin to Modify Endogenous Mechanisms of Malignancy Selectively Targets Cancer Cells Enhances Anti-cancer Drug Effects Very Low Doses of Chemotherapeutic Agents Almost Completely Eliminates Dose Related Side Effects.

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Insulin Receptors (IRs) & Cancer Cells

# of IRs on cancer cells is much greater than nl cells IR count correlates with tumor size and histological grading. The binding capacity and affinity for 125-I labeled insulin was found to be 9 times as great in breast cancer cells than normal cells. IRs do not down regulate as readily and can have 1000 fold resistance to receptor down-regulation.
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Mammals have 100 to 100,000 insulin receptors per cell. Cancer cells have from 6 to 17 times more IRs per cell than non-cancer cells.
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Insulin & Cancer Cells

1) Insulin stimulates cell replication. 2) Insulin is produced by cancer cells (i.e. biopsy specimens produce insulin) 3) Cytoplasmic B-subunit of Insulin has tyrosine kinase activity (oncogene product) 4) insulin resistance increases cancer risk.
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Elevated IGF levels Hodgkins & Non-Hodgkins Lymphoma Renal Adenocarcinoma Cervical & Uterine Carcinoma Breast, Colon, and Lung Carcinoma Lymphoblastic leukemia Amount of IGFs correlates with stage Cancer cells have up to 10 times more IGF receptors on their surfaces. Treatment causes the IGF levels to decrease.
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Insulin and IGF-1 operate autonomously at the cellular level within tumors to promote tumor growth.

IGF-1 is the major anabolic hormone while insulin regulates and provides the fuel for these processes.

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Rapidly growing tumors are more sensitive to chemotherapy than slow-growing tumors. Studies at George Washington University, National Cancer Institute and M.D. Anderson Hospital & Tumor Institute tested and proved that insulin does potentiate the effects of chemotherapy.

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Hence, the results of our experiments indicate that tumor-specific growth stimulatory hormones can be utilized to overcome the cyto-kinetic drug resistance. thereby render subpopulations of tumor cells vulnerable to the lethal effects of cell cycle-active drugs that otherwise would have remained inert to their effects and might have constituted a potential source of late treatment failure.

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After IV Insulin: Membrane Effect Improved drug penetration into cancer cells Use lower doses to reduce side effects Shorten treatment cycle intervals Metabolic Effect Increased proportion in S phase. Increase rate of cell kill per cycle Cellular Differentiation Effect Excess IR & IGF-R on cancer cells Specifically targets cancer smart bomb Relative sparing of normal tissue from toxicity
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In vitro, after adding insulin to an asynchronous population of breast cancer cells, the S phase fraction was 66% compared to only 37% in the controls.
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From Treating Cancer with Insulin Potentiation Therapy p 84 by Ross Hauser, M.D. 2002 Pub: Beulah Land Press
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Insulin and Appetite

IPT changes the pathophysiology of the fatigued, depressed and anorexic patient.

Insulin stimulates appetite Results in weight gain Produces euphoria

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Human breast cancer cells have six times more insulin receptors (1) and ten times more IGF-I receptors (2) than normal tissues in the body.
1) Holdaway IM, Freisen HG. Hormone binding by human mammary carcinoma. Cancer Res 37:1946-1952, 1977

2) Cullen JK et al. IGF-I receptor expression and function in HBCC. Cancer Res 50:48-53, 1990
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Insulin enhanced the cytotoxic effect of methotrexate in MCF-7 human breast cancer cells in vitro by a factor of up to ten thousand. (that is 10,000 fold )
Alabaster O, Vonderhaar BK Shafie SM. Metabolic modification by insulin enhances methotrexate cytotoxicity in MCF-7 human breast cancer cells. Eur J Cancer Clin Oncol 17:1097-1103, 1981

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Preincubation of MDA-MB-231 human breast cancer cells in vitro with insulin resulted in an increased intracellular accumulation of ellipticine with a concomitant increase in cytotoxicity.
Oster JB, Creasey WA. Enhancement of cellular uptake of ellipticine by insulin preincubation. Eur J Cancer Clin Oncol 1981, 17:1097-1103
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Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells
Ke ZOU1,2, Ji-hang JU1,2, Hong XIE1

Conclusion: These data suggest that insulin enhances anticancer functions of 5-FU when it is treated before 5-FU for the appropriate time in human esophageal and colonic cancer cell lines.
PUB Acta Pharmacol Sin 2007 May; 28 (5): 721730 2007
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The effect of insulin on chemotherapeutic drug sensitivity in human esophageal and lung cancer cells
JIAO Shun-Chang, HUANG Jing,

Conclusion As a reversible metabolic promoter, insulin enhances the cytotoxity of the chemotherapeutic agents. It is possible to increase the growth and metabolism of cancer cells first, in order to enhance the chemosensibility, and then administer chemotherapeutic agents, thus improving their therapeutic effects.
PUB: Natl Med J China, February 10, 2003; Vol 83, No 3, Page 195-197.
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Insulin fuels Cancer

Cancer cells eat glucose Cancer cells have 6x > insulin receptors Insulin allows greater membrane permeability for glucose Cancer cells have 10x > IGF-1 receptors IGF-1 increases S phase (growth phase) Synergetic membrane & metabolic effect Elegant medicine: think PO vs. IV ABX
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Summary: Biochemistry of Insulin and Cancer

Glucose is the ONLY fuel cancer cells can use Cancer cells have 6 to 17x > IRs than regular cells Cancer cells have 10 x > IGF-1 Rs than regular cells INS+IR increases delta-9-desaturase which makes cancer cells become permeable IGF-1 doubles number of cancer cells in S-phase; increasing vulnerability to chemotherapy drugs Cancer cells are selectively targeted so lower doses of chemo drugs preserves immune function Appetite improves, weight and euphoria increase
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Insulin Potentiation Therapy

IPT is a chemotherapy-based protocol using insulin as a biologic response modifier of the endogenous mechanisms of malignancy. In IPT, insulin is used to selectively target cancer cells with lowered doses of chemotherapy drugs, enhancing drug effects on these cells and, at the same time, effectively reducing doserelated chemotherapy side effects on host normal tissues.

The Nature of Cancer 1) Aggressive or not? 2) Curable or not? 3) Infectious or not? 4) What is the role of mind/body?

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The Mechanisms of Malignancy

The combination of insulin and IGF-I operates autonomously at the cellular level within tumors, and this operation is free from any higher level of integrated control

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The Mechanisms of Malignancy

(cont.)

The two work together in an autocrine and/or paracrine manner and in a complementary fashion, with IGF-I being the major anabolic hormone responsible for mediating messages about growth in the tumor, while insulin regulates and provides the fuel for these processes.
Zapf J., Froesch E.R. Insulin-like growth factors/somatomedins: structure, secretion, biological actions and physiological role. Hormone Res 24:121-130, 1986.
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Nature abhors a vacuum.

Empty or unfilled spaces are unnatural as they go against the laws of nature and physics.
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Cancer is not the problem.

Cancer is an adaptive response to the problem.

Toxic blood and tissue is the Problem

Every town has a garbage dump. Solution: make less trash, recycle. To avoid cancer: eat non-toxic foods and eat less!
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Removing the tumor is the least important step in curing cancer.

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The Three Steps

1) Take down cancer welcome sign 2) Enhance immune system 3) Reduce or kill cancer cells

Metaphor: Bailing a sinking boat vs. plugging the hole

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The Four Bodies The Violin Concert

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Corrective Cancer Care

The Health Pyramid The NET Nutrition Exercise Thought
Hospital Drugs Surgery

Supplement
and / or

Detoxify

LIFESTYLE FACTORS (85%) Repair the NET Nutrition (get it) Exercise (use it) Thoughts (manage it)

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Nutrition
What comes in all 7 senses Quality organic fresh Adequate protein Haelan 951 Supplements: MVMM Soul food
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Supplements
Prevent cancer cells from repairing themselves (caffeine) Force apoptosis (curcumin, tumeric) Support immune system
1. 2. 3. 4. 5. 6. Theanine (increases interferon gamma) Arginine (increases NKC and T-cell function) American ginseng (increases T-cell function) Melatonin (increases IL-2, epidermal growth factor) Avemar (increases T-cell function) Vitamin C and others

Prevent Metastases - Modified Citrus Pectin, Heparin, Thalidomide. All of the above and more: Haelan 951
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Haelan 951
a raw, fermented, organic, non-GMO, whole soy product This product contains all 5 of the super foods discovered in 1991 by the National Cancer institute after their $20 million study searching for anti-cancer properties in fruits and vegetables: 1) Isoflavones 2) Protease Inhibitors 3) Saponins 4) Phytosterols 5) Phytic Acid Compounds
(Journal of the National Cancer Institute April 17,1991)

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Haelan 915 Benefits

1) Apoptosis is stimulated: Clinical Implication: Apoptosis is the healthy, appropriate cells death which occurs at the right times after a cell has lived it full normal life. In contrast, cancer cells resist apoptosis and live eternally thereby killing the cancer patient.

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Haelan 915 Benefits (cont.)

2) DNA Repair is enhanced. Clinical Implication: DNA damage is the hallmark of cancer. If DNA is repaired a cell can stop being cancerous. 3) Reactivates P-53 Tumor Suppressor Gene Clinical Implication: This raises levels of P-21 in breast, ovarian and prostate cancer cell and thereby suppresses cancer and allows apoptosis.
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Haelan 915 Benefits (cont.)

4)P21 gene activity is increased Clinical Implication: This lifesaving gene is derived from the anti-cancer gene P53 and allows to cancer call death 5) Anti-angiogenesis Clinical Implication: Angiogenesis is the creation of a blood supply to tissues low in oxygen. Without this new blood supply, cancer cells can not grow. Avastin stops angiogenesis by destroying VEGF (vascular endothelial growth factor) systemically which is fatal. Haelan 951 stops angiogenesis without destroying VEGF.
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Haelan 915 Benefits (cont.)

6) Reduces exosomes Clinical Implication: These are particles that inhibit immune defense against cancer, they inhibit both NK cell function and gamma interferon. 7) Increases BAX 500% compared with the drug Doxorubicin (in cases of breast cancer) Clinical Implication: This is a gene which kills cancer cells via allowing apoptosis.

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Haelan 915 Benefits (cont.)

8) Decreases BCL2 200% - in comparison to Doxorubicin (in cases of breast cancer) Clinical Implication: This is a gene which allows cancer cells to thrive by evading apoptosis. 9) Improves Anti-apoptotic Ratio of BAX/BCL2 Clinical Implication: This means that the genes are now fighting cancer by enhancing apoptosis.

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Haelan 915 Benefits (cont.)

10) Reduces Estrogen Levels Clinical Implication: This is an anti-cancer effect since it also reduces ER-a.

11) Increases Estrogen receptor-beta receptors Clinical Implication: These kill cancers by increasing the amount of natural chemotoxic agents like 2-methoxyestradiol as well as their delivery to the cancer cell.

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Haelan 915 Benefits (cont.)

12) Decreases Estrogen receptor-alpha receptors ER-a Clinical Implication: These receptors allow cancer cells to thrive and metastasize so they must be suppressed for your health. 13) Improves Ratio- ER-a/ER-b Clinical Implication: This allows for appropriate apoptosis and restoration of low cancer risk.

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Haelan 915 Benefits (cont.)

14) Decreases the matrix metalloproteinases enzyme Clinical Implication: This enzyme erodes collagen surrounding the tumor and frees cancer stem cells to spread through out the body creating metastatic disease. 15) Produces Anti-Cancer metabolites Clinical Implication: Some of the most important of these are 3-Beta Adiol and 2-methoxyestradiol which hunt down and kill cancer stem cells.
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Haelan 915 Benefits (cont.)

16) Prevents Protein Calorie Malnutrition (cachexia or starvation) Clinical Implication: This reversal of cachexia is life-saving since cachexia kills 80% of cancer patients. We must at all costs avoid the situation where you starve (no appetite!) while the cancer gorges itself.

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Haelan 915 Benefits (cont.)

17) Decreases Viral and Bacterial Burdens Clinical Implication: Haelan 951 cleans house and allows the immune system to work without distraction. 18) Increases function of GADPH gene expression Clinical Implication: This gene expression is one way to measure cancer die off.
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Haelan 915 Benefits (cont.)

19) Shuts Down NF-kB Mutation Pathway Clinical Implication: Cancer cells are smart and they try to mutate using the NF-kB pathway in order to escape death when the immune system or the chemotherapy is applied. 20) Enhances tumor necrosis factor (TNF) Clinical Implication: TNF is a pillar of our immune system required to fight cancer.

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Haelan 915 Benefits (cont.)

21) Non-Specific Immune Stimulation Increased 400% Clinical Implication: the symbiosis of taking a product offering the 5 super foods (Haelan 951) and the myriad benefits described above amount to a huge immune boost. It increases macrophage phagocytosis by three-fold and double the number of active macrophages.

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Haelan 915 Benefits (cont.)

22) Gives clearer margins for surgical removal of tumors Clinical Implication: If surgery is indicated, the goal is 1) to remove the cancerous cells and 2) to cut away leaving a clean margin meaning leaving no residual cells. 23) Overcomes depression and improves quality of life Clinical Implication: When the soul and spirit are less troubled, the immune system thrives.
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Curcumin, the yellow pigment found in the spice turmeric and a key ingredient in yellow curry inhibits melanoma cell growth and stimulates tumor cell death via apoptosis
potent antioxidant, anti-inflammatory and cancer terminating effects CANCER August 15, 2005
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Proteolytic Enzymes

(away from food):

1) selectively attack and kill cancer cells 2) clean up after themselves (debris) 3) unmask cancer cells (membrane effect) 4) prevent metastatic disease 5) offer systemic immune enhancement 6) compelling scientific /clinical record 7) excellent risk/benefit ratio
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VITAMIN D3
A preponderance of evidence from the best observational studies... has led to the conclusion that public health action is needed. Primary prevention of these cancers has been largely neglected, but we now have proof that the incidence of colon, breast and ovarian cancer can be reduced dramatically by increasing the public's intake of vitamin D."
Professor Cedric Garland the University of San Diego, California after reviewing 63 recent studies on vitamin D and cancer.
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Vitamin C plus Vitamin K3

1. Vitamin K3 alone has demonstrated anti-tumor activity against multiple rodent and human cancer cell lines. 2. Synergism noted with doxorubicin, 5 FU, vinblastine, vincristine, mitomycin, bleomycin, cisplatin, mitoxanthrone, MTX, and many others.

3. Phase I trials in humans 400-500 mg/day showed no toxicity in combination with mitomycin. Phase II trials of IV K3 (2.5 gms/m2) with mitomycin showed objective response but 30% BSW 2010 showed hemolysis (Gold,(c)Cancer Treat Rep, 1986)

Vitamin C Plus Vitamin K3 contd

1) Vit C and K3 combination showed synergistic activity in a 100/1 ratio in breast, endometrial and oral epidermoid carcinoma cell lines in concentrations 10-50 times lower than for the individual vitamins (Noto, et al, Cancer, 1989). 2) Co administration of C plus K3 with adriamycin, bleomycin, mitomycin C, vincristine or cisplatin increased growth inhibitory effect by 3-14 fold
(Buc Calderone, et al., Curr. Med. Chem. 2002).

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Vit C and K3: The Mechanism of Action

High levels act via oxidative stress and are cytotoxic via necrosis or autoschizis. Low levels kill by a non-oxidative mechanism involving transcription factors to produce autochizis and apoptosis.

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Vitamin C: Cancers silver bullet

1. Vitamin C alone has been found to have cytotoxic effects against most cancer cell lines in vitro. These in vitro concentrations are easily achievable in vivo with IV C. The mechanism appears to be intracellular accumulation of H2O2 with low catalase enzyme activity native to cancer cells. (Dr. Mark Levine, NIH division of Diabetes and
Kidney diseases).

2.

Vit C has also been found to potentiate the effects of chemotherapy drugs (Zaizen, et al., J cancer Res Lin Oncol,
1986; Prasad, et al, Pol J Pharmacol and Pharm, 1992; Koch and Biaglow, J Cell Physiol, 1978) and radiation therapy (Hanck, Prog Clin Biol Res, 1988).

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Oxygen breathing may be a cheaper and safer alternative to exogenous erythropoietin (EPO) Recently discovered normobaric oxygen paradox demonstrates that renal tissue can be stimulated to increase EPO production via a simple pattern of oxygen breathing at normal atmospheric pressures. This leads directly to the hypothesis that oxygen breathing may provide chemotherapy patients with a convenient and inexpensive alternative to ESAs. Stimulating endogenous EPO production eliminates the small risk of immune system reaction associated with ESAs. Further, the endogenous physiological EPO doses provided by this method may be safer, in terms of cancer mortality, than the exogenous pharmacological doses inherent in ESA administration. Author: R. Burk Medical Hypothesis published on line 5/ 11/ 07
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Specific nutritional supplements given IV after insulin but before therapeutic moment
Resveratrol
Theanine Glutamine Acetyl-L -carnitine Artemisinin
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Quercetin
Proline Arginine Niacinamide N- Acetyl Cysteine

Exercise
Activity Doing justice to what comes in Processing Digesting Expression Creativity (our birthright!)

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Thought
CorThot Thoughts create feeling Feelings are transient Thoughts are directable Reason for living Quality of life

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Case#1: Hodgkins Lymphoma stage IV

65 year old male, otherwise healthy Lump on neck no other symptoms PET results February 2010: Multiple areas of abnormal metabolic activity seen in head and neck. Abnormal metabolic activity seen along retroaortic thoracic lymph node. L3-L4 skeletal lesions. Impression: stage IV Hodgkins lymphoma with multiple stations of adenopathy in head and neck, chest, abdomen and pelvis.
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Proposed Treatment
Meds: Bleomycin Assurance: Dont worry. We have an excellent success rate with Hodgkins Lymphoma: 6 months of Hell and then 2 years of recovery, but after that, you will be cancer free.

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Conventional Treatment Course

2 treatments of conventional chemotherapy: Vinblastine, Cytoxan, Adriamycin, Prednisone, Procarbazine, Omeprazole, Prochlorperazine Side effects: nausea, Never again. Id rather die.

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CCC starting April 2010

1) IPT chemotherapy: Bleomycin 1 unit, Adriamycin 6mg, Dacarbazine 20mg, Vinblastine 1mg. 2) HDVC: 50g /450cc sterile water w/ 2cc Magnesium SO4 3) Alpha Lipoic Acid 600mg in 50cc nl saline 4) Homeopathics: Au Stibium Hyoscyamus Hepar Stannum 6/10 Lien Cichorium Lymphocytes 8 Thrombocytes 6 Erythrocytes 6

Oral Supplements: Haelan 951, MVMM, Niacin, Selenium, CoQ 10, vitamin D3, LDN 4.5mg

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Clinical Progress
PET/CT 4-14-10: IMPRESSION: remarkable improvement since 2-2-10 with near complete response. Oncologist: My treatment has kicked in. Patient goers off protocol: alcohol, sugar PET/CT 6-11-10: enlarged nodes on both sides of the neck, supraclavicular space and the mediastinum, retrocrural lymph nodes, skeletal lesions at L3L4. Disease progression seen compared to 2-2-10 PET/CT. Patient leapt back on CCC protocol.
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PET: 8/6/10
Head and Neck no evidence of adenopathy no focal lesions to suggest recurrence in the head and neck. Chest no abnormal metabolic activity seen in nodes no new lesions no suspicious pulmonary nodes Abdomen: no organomegaly, no adenopathy Skeleton: No focal suspicious lytic or blastic skeletal lesions seen. Impression: No PET CT evidence for residual or recurrent lymphoma.
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Case #2: Leiomyosarcoma (uterine) stage IV with mets to Lung

51 yr old woman, onset age 47

Failed surgery, chemotherapy, and radiation. Gemzar & Taxotere, Adriamycin & Cis Platin, Ifosfamide & Mesna & Adriamycin, Gemzar & Taxotere, Dacarbazine, Yondelis trial PET/ CAT Jan 2010 Innumerable metastatic pulmonary lesions aggressive disease. Tumor markers Jan 2010 CA 125=173, CA 19-9 =70 I am shocked it came back so quickly. Put your affairs in order Seattle oncologist refused more care
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CCC starting March 2010

1) IPT: Cytoxan 150mg, Gemzar 200mg, Methotrexate 12.5mg 2) HDVC: 50g /450cc sterile water w/ magnesium SO4 3) Alpha Lipoic Acid 600mg in 50cc nl saline 4) Homeopathics:
Au Stibium Hyoscyamus Lien Cichorium Thrombocytes 6 Hepar Stannum 6/10 Lymphocytes 8 Erythrocytes 6

Oral Supplements: Haelan 951, MVMM, Niacin, Selenium, CoQ 10, vitamin D3, LDN 4.5mg
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Radiographic Progress
PET/CAT April 2010: The innumerable bilateral pulmonary metastatic lesions have shown substantial decrease in size and number. None of these lesions shows a significant degree of metabolic activity. Abdomen/pelvis: stable, no evidence of local recurrence of metastatic disease. PET/CAT July 2010: Essentially all of the preexisting metastases are smaller and/or less dense of current exam. No new lung metastasis.
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Tumor Markers
DATE January 2010 CA 125 138 CA 19-9 41

March 2010
June 2010 September 2010

53
18 15
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33
49 35

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Case #3 Fallopian tube cancer with mets to Lung

67 yr old woman s/p breast cancer 1994 (mastectomy with adjuvant chemotherapy and Tamoxifen) then fallopian tube cancer 2000 then recurrence with mets to lung 2008. Tumor Markers 6/10: CA 125 = 8883 CA 19-9 = 98 PET/CT 5-29-10: Interval worsening persistent abnormal uptake, persistent hypermetabolic adenopathy
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CCC starting June 2010

1) IPT Chemotherapy drugs: Cisplatin 5-10mg vs. Carboplatin 25-50mg, with Gemzar 50-100-200mg, 2) HDVC: 50g /450cc sterile water w/ magnesium SO4 3) Alpha Lipoic Acid 600mg in 50cc nl saline 4) Homeopathics: Au Stibium Hyoscyamus Hepar Stannum 6/10 Lien Cichorium Lymphocytes 8 Thrombocytes 6 Erythrocytes 6 Oral Supplements: Haelan 951, MVMM, Niacin, Selenium, CoQ 10, vitamin D3, LDN 4.5mg
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Tumor Markers
DATE June CA 125 8883 CA 19-9 98

July
August September

3249
1314 873
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92
60 40

The original Come Hither look.

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Case #4

Colorectal Adenocarcinoma

Nov 2006 A 65 yr old man noted a mass protruding from anus and blood in stool. Thought it was hemorrhoids so did nothing for 11 months! October 2007 doctor does a DRE and notes large mass Dx from Bx: Stage IV Colorectal Adenocarcinoma December 2007 CAT rectal mass and liver met 7mm

March 2008 Pt. refused chemo, took radiation (28 rounds of external beam) and Arimidex. Doing lots of nutritional supplements. Comes for IPT.
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Case 3 Colorectal CA contd

CEA 12.3 on 10-22-07 He was started on alternating IPT regimen 2X/wk 5-FU 250mg, Mitomycin 2mg, Leukovorin 10mg 50 c cnl saline SIVP before the 5FU in , IM Intron rectal ozone insuflation alternate with 5-FU 250mg, Leukovorin 10mg in 50 cc nl saline with Irinotecan 20mg/cc or Oxaliplatin 10mg with Ribavarin 200mg rectal ozone insuflation On 12-03-07 CEA 19.8 ng/ml (nl <2.5) CA 19-9 66 u/ml (nl < 37) On 12-26-07 CEA 16.9 ng/ml , CA 19-9 59 u/ml On 4-10-08: CAT shows tumor shrunk 50%, CEA 1.6, CA-19-9 20 Total IPT treatments = #18 Total HDVC Thiotic Acid Glutathione =#38 On 5-19-08: Surgery on reduced tumor was successful On 10-19-08 CEA <.5 ng/ml (nl <2.5) CA 19-9 23 u/ml (nl < 37)

Colostomy, but alive and active and back to work.

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CCC starting October 2007

IPT: alternating IPT regimen 2X/wk: 1) 5-FU 250mg, Mitomycin 2mg, Leukovorin 10mg 50 cc nl saline SIVP before the 5-FU alternate with 2) 5-FU 250mg, Leukovorin 10mg in 50 cc nl saline with Irinotecan 20mg/cc or 3) Oxaliplatin 10mg with Ribavarin 200mg With Intron IM and rectal ozone insuflation
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The rest is standard

2) HDVC: 50g /450cc sterile H2O w/ mag SO4 2 cc 3) Alpha Lipoic Acid 600mg in 50cc nl saline 4) Homeopathics:
Au Stibium Hyoscyamus Lien Cichorium Thrombocytes 6 Hepar Stannum 6/10 Lymphocytes 8 Erythrocytes 6

Oral Supplements: Haelan 951, MVMM, Niacin, Selenium, CoQ 10, vitamin D3, LDN 4.5mg
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CEA REPORTS
Date Results 10/22/07 12.3 12/03/07 19.8 12/26/07 16.9 01/07/08 15.6 04/09/08 1.6 07/09/08 Less than 0.5 10/19/08 Less than 0.5 01/21/10, 4/21/10, 7/21/10 - all Less than 0.5 The oral chemotherapy chlorine dioxide started 12/14/07. Radiation therapy February through March 2008. Surgery to remove the cancer May 9th of 2008.
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November 3, 2008 Dear Dr. Weeks, Attached is a record of my CEA results correlated with treatment modalities. IPT was very effective with no sideeffects and allowed my surgery to be minimal and now I feel fine. I have been keeping track of the billings for conventional treatments. The total for surgery and radiation treatment is in excess of $150,000 but I do not have an exact figure. If I had accepted the chemotherapy that was repeatedly thrust upon me the bill would have been considerably higher. I am grateful to you and the pioneers who are practicing IPT.
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2010 Follow-up of Case 3

Dear Brad, It is good to hear from you. My health continues to be good and, considering all of the surgery, my energy and ability to function and work are good. My emotional health and sense of wellbeing are also good. IPT was a life saver.

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For health maintenance I take a daily dose of seawater mineral extract that I make, a tablespoon of wheat germ oil and 1,000 mg of vitamin C. On every day that the sun does not shine I take 10,000 IU of vitamin D-3. About once each week I take an Iodoral tablet. Each night before bed I take a 3 mg tablet of melatonin and 1.25 oz of rum. Once every 60 days I take San Pedro cactus extract. At the first sign of any serious physical problem I would not hesitate to began a course of MMS treatment. Have you noticed that MMS has now been suppressed by the FDA?
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2) Antioxidants and immune enhancing protocols do not interfere with IPT but rather enhance benefit and are protective of healthy cells and vitality. 3) Patients find the experience not unpleasant (aside from the therapeutic moment of low blood sugar). 4) Side-effect free effective chemotherapy is here!

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Summary and Invitation

Corrective Cancer Care with Insulin Potentiation Therapy
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The Standard of Care is sub-therapeutic. Only 10% of conventional oncologists say they would take the medication they prescribe if they had cancer.

In contrast, 100% of IPT doctors would take their own medicine!

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"I die by the help of too many physicians."

Alexander the Great
on his deathbed, 323 B.C.

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Corrective Cancer Care with IPT

Safe Effective Cost-effective
and

The longest continuous cancer chemotherapeutic protocol in the western hemisphere (1926-present)
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Corrective Cancer Care with IPT

cont.

Smart Bomb effect: Excess of insulin-

sensitive receptors on human cancer cells causes predominance of insulin effect in cancer cells, sparing normal host tissues = INCREASED SAFETY
Synergy of insulins membrane and metabolic effects enhances anticancer drug action in cancer cells = INCREASED EFFICACY
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Why we offer beyond the standard of care therapies?

1) more effective treatment 2) more grateful patients 3) more personal and professional satisfaction
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Quality of Life
1) Appreciate all things at all times 2) Laugh and cry 3) Be Curious and allow surprises 4) Participate (walk the dog!) and 5) Appreciate all over again!
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Rory reminding us to take the time BSW to stop and smell (c) 2010 flowers! the

Dear Dr. Weeks, After my amazing treatments at your wonderful clinic, I feel so fantastic that I think I can walk on water. But I know that you can!
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We all can walk on water. It is only a matter of motivation.

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WELCOME TO VISIT US IN SEATTLE !

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Walking on Ebbys Landing Whidbey Island, with Rory.

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Well have some fun!

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