Professional Documents
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L
Assistant Professor
Dept of Physiology
SSMC
HAEMOGLOBIN
• INTRODUCTION
• STRUCTURE
• TYPES
• SYNTHESIS
• FATE
• DERIVATIVES
• CLINICAL- ANAEMIAS
- HAEMOGLOBINOPATHIES
- PORPHYRIAS
• Pigment present inside RBCs
PORPHOBILINOGEN
PROTOPORPHYRIN IX
Fe2+ haem synthase
HAEM
GLOBIN
HAEMOGLOBIN
FATE OF HAEMOGLOBIN
• RBCs are destroyed in RES ( mainly spleen
and bone marrow) after 120 days of life.
H aem G lo b in
P r o t o p o r p h y r in Iro n CO A m in o a c id p o o l
B iliv e r d in ir o n p o o l
B ilir u b in
DERIVATIVES OF Hb
1) Oxyhaemoglobin (HbO2) – oxygenation reaction
– combination with Fe 2+
5) Sulfhaemoglobin
# ANAEMIAS
# HAEMOGLOBINOPATHIES
# PORPHYRIAS
ANAEMIAS
Classification:
I . Based on severity.
v) Mild – 8-12gm/dL
vi) Moderate – 5-8gm/dL
vii) Severe - < 5gm/dL
II) Based on morphology of RBCs