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NCM 401
Objectives:
At the end of this concept, the students will be able to: 1. Define key terms 2. Describe related epidemiological data 3. Identify causes of bipolar disorder 4. Explain the cognitive changes as they occur in various levels of bipolar disorder 5. Discuss the: a. role of neurobiological and psychosocial factors in bipolar disorders b. diagnostic criteria-DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders) for each type of bipolar disorders c. treatment modalities
Objectives:
Given a specific type of bipolar disorder, the students will be able to: 6. Asses the presenting s/sx using DSM-IV TR diagnostic criteria 7. Identify at least 4 relevant NDx 8. Submit a NCP (must include strategies to support family adaptation) Given hypothetical questions on the mood and behavioral changes of a patient with bipolar disorder, the students will be able to 9. State the appropriate caring behavior 10. Integrate Christian values
Key Terms:
Affect: emotional display or observable behaviors that are the expression of an experienced, subjective feeling. Examples of affect that are appropriate, blunted, flat, inappropriate, labile, restricted or constricted. Bipolar: the two extreme mood states of mania and depression illustrated in bipolar disorder Circumstantiality: a thought and speech process in which an individual digresses into unnecessary details and inappropriate unrelated thoughts while trying to express a central idea Cyclothymia: a condition in which numerous periods of abnormally elevated, expansive or irritable moods are experienced interspersed with periods of depressed mood Distractibility: the inability to maintain attention, shifting from one area or topic to another with minimal provocation, or attention being drawn too frequently to unimportant or irrelevant external stimuli. Dysphoria: a mood of general dissatisfaction, unpleasantness, restlessness, anxiety, discomfort and unhappiness observed in depressive states. Euphoria: an exaggerated feeling of well being or elation
Key Terms:
Flight of ideas: over productive speech characterized by rapid shifting from one topic to another and fragmented ideas Grandiosity: an inflated appraisal of ones worth, power, knowledge, importance, or identity and may include delusional thinking Mood: a consistent emotional state experienced by an individual over time that influences her perception of the world. Ex: dysphoric, elevated, expansive, euphoric, or irritable Pressured speech: disturbance in verbal expression of thought characterized by an overproduction of rapid speech that is frequently loud, unsolicited by social interaction, and difficult to interrupt. Racing thought: a rapid series of ideas that occur during manic episodes Rapid cycling: a type of bipolar disorder characterized by at least four episodes of depression, mania, or mixed states each year Tangentiality: a speech pattern that illustrates an inability to respond completely in a focused manner. Individuals may begin to respond appropriately but progress to related topics, never completing the originally desired response.
Bipolar Disorder
Causative Factors:
Theories and Perspectives 1. Psychodynamic, Existential, Cognitive-Behavioral and Developmental theories 2. Biological theories/Genetic Factors Biological theories Neurochemical and Neuroendocrine factors= Biogenic Amine theory Neuroanatomical factors Genetic Factors Genes located on the region of chromosome 18identification of region 22.3 of chromosome 21 and chromosome 11 Chronobiology study Kindling theory
Psychodynamic
Freud: looked at the self-depreciation of people with depression and attributed that selfreproach to anger turned inward related to either real or perceived loss. Feeling abandoned by this loss, people become angry while both loving and hating the lost object. Jacobson: compared the state of depression to a situation in which the ego is a powerless, helpless child victimized by the superego, much like a powerful sadistic mother who takes delight in torturing the child.
Example:
Traumatic events (loss of a child)
Feelings of self-loathing, shame, or guilt Feeling hopeless, sad, or empty. Loss of interest in things you used to enjoy
Existential Theory
Existential theorist believed that behavioral deviations result when a person is out of touch with himself or the environment. The person who is self-alienated is lonely, sad and feels hopeless. Lack of self awareness, coupled with harsh criticism, prevents the person from participating in satisfying relationships. The person is not free to choose from all possible alternatives because of self imposed restrictions. The person is avaoiding personal responsibilities and giving it to the wishes or demands of others.
Neuroendocrine influence
Elevated glucocorticoid activity is associated with the stress response, and evidence of increased cortisol secretion is apparent in about 40% of clients with depression with the highest rates found among older clients. Post partum hormone alterations precipitate mood disorders such as postpartum depression About 5%-10% of people with depression have thyroid hormone dysfunction, notably an elevated TSH.
Chronobiology study
The variations of the timing and duration of biological activity in living organisms occur for many essential biological processes. The most important rhythm in chronobiology is the circadian rhythm, a roughly 24 hour cycle shown by physiological processes
Functional Impairment (all decreased) -memory performance -verbal memory (recall of a story or single word) -attention dysfunction -verbal learning -verbal fluency -Psychomotor speed -declarative memory (conscious recollection of facts and events)
Comorbidity-Substance abuse Bipolar Alcohol Drugs 46% 41% Unipolar 21% 18%
MANIA
Distinct period during which mood is abnormally and persistently elevated, expansive, or irritable. Period lasts 1 week(unless hospitalized and treated sooner) Plus at least 3 of the following symptoms: inflated selfesteem/grandiosity; decreased need for sleep; pressured speech; flight of ideas; distractibility; increased involvement in pleasureseeking activities with a high potential for painful consequences Some exhibit delusions and hallucinations
HYPOMANIA
less severe form of mania Period of abnormally elevated, expansive, or irritable mood lasting for 4 days plus 3 or 4 of the additional symptoms as described in mania never suffer from delusions and hallucinations able to carry on with their dayto-day lives often escalates to full-blown mania or is followed by a major depressive episode
BIPOLAR DEPRESSION
Last at least 2 weeks of depressed mood or loss of pleasure in nearly all activities plus four of the ff symptoms changes in appetite or weight, sleep, or psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. These symptoms must be present everyday for 2 weeks and result in significant distress or impair social, occupational, or other important areas of functioning. Some have delusions and hallucinations---psychotic depression
MIXED
experiences both mania and depression nearly everyday for at least one week Often called rapid-cycling
Specify if: MIXED: if sx meet criteria for a mixed episode If the full criteria met for a manic, mixed, or major depressive episode, specify its current status and of features: Mild, Moderate, Severe w/o psychotic features With catatonic features With postpartum onset If the full criteria have not currently met for a manic, mixed, or major depressive episode, specify the current clinical status of the bipolar I disorder or features of the most recent episode In partial Remission, In Full Remission With catatonic features With postpartum onset
If the full criteria currently met for a manic episode, specify its current status and of features: Mild, Moderate, Severe w/o psychotic features With catatonic features With postpartum onset If the full criteria are not currently met for a manic episode, specify the current clinical status of the bipolar I disorder or features of the most recent manic episode In partial Remission, In Full Remission With catatonic features With postpartum onset
Bipolar I Disorder, Most Recent Episode Mixed A. Currently (or most recently) in a Mixed Episode. B. There has previously been at least one Major Depressive Episode, Manic Episode, or Mixed Episode. C. The mood episodes in Criteria A and B are not better accounted for by Schizoaffective Disorder and is not superimposed on Schizophrenia, Schizophreniform Disorder, Delusional Disorder, or Psychotic Disorder Not Otherwise Specified.
If the full criteria currently met for a Mixed episode, specify its current status and of features: Mild, Moderate, Severe w/o psychotic features With catatonic features With postpartum onset If the full criteria are not currently met for a Mixed episode, specify the current clinical status of the bipolar I disorder or features of the most recent Mixed episode In partial Remission, In Full Remission With catatonic features With postpartum onset
Bipolar I Disorder, Most Recent Episode Depressed A. Currently (or most recently) in a Major Depressive Episode. B. There has previously been at least one Manic Episode or Mixed Episode. C. The mood episodes in Criteria A and B are not better accounted for by Schizoaffective Disorder and is not superimposed on Schizophrenia, Schizophreniform Disorder, Delusional Disorder, or Psychotic Disorder Not Otherwise Specified.
If the full criteria currently met for a major depressive episode, specify its current status and of features: Mild, Moderate, Severe w/o psychotic features/Severe w/ psychotic features Chronic With catatonic features With melancholic features With atypical features With postpartum onset If the full criteria are not currently met for a major depressive episode, specify the current clinical status of the bipolar I disorder or features of the most recent major depressive episode In partial Remission, In Full Remission: Chronic With catatonic features With melancholic features With atypical features With postpartum onset
Bipolar II Disorder Hypomania and depression doesnt experience full-blown manic episodes illness involves episodes of hypomania and severe depression experienced at least one hypomanic episode and one major depressive episode
Specify current or most recent episode: Hypomanic: if currently (or most recently) in a hypomanic episode Depressed: if currently (or most recently) in a major depressive episode
If the full criteria have currently met for a major depressive episode, specify the current clinical status of the bipolar I disorder or features: Mild, Moderate, Severe w/o psychotic features/Severe w/ psychotic features Chronic With catatonic features With melancholic features With atypical features With postpartum onset
If the full criteria are not currently met for a hypomanic or major depressive episode (only if it is the most recent type of mood episode)
In partial Remission, In Full Remission: Chronic With catatonic features With melancholic features With atypical features With postpartum onset
Note: After the initial 2 years (1 year in children and adolescents) of Cyclothymic Disorder, there may be superimposed Manic or Mixed Episodes (in which case both Bipolar I disorder and Cyclothymic Disorder may be diagnosed) or Major Depressive Episodes (in which case both Bipolar II Disorder and Cyclothymic Disorder may be diagnosed)
D. The symptoms in Criterion are not better accounted for by Schizoaffective Disorder and is not superimposed on Schizophrenia, Schizophreniform Disorder, Delusional Disorder, or Psychotic Disorder Not Otherwise Specified.
E. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication) or a general medical condition (e.g., hyperthyroidism).
F. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
Diagnostic Criteria for Mood Disorder due to (indicate the general medical condition)
A. A prominent and persistent disturbance in mood predominates in the clinical picture and is characterized by either (or both) of the FF: the depressed mood or markedly diminished interest or pleasure in all, or almost all activities elevated, expansive, or irritable mood B. There is evidence from the history, PE, or lab findings that the disturbance is the direct physiological consequence of a general medical condition C. The disturbance is not better accounted for another mental disorder (ex: Adjustment disorder with depressed Mood in response to the stress of having a general medical condition) D. The disturbance does not occur exclusively during the course of a delirium E. The sx cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
Specify Type: With Depressive features: if the predominant mood is depressed but the full criteria are not met for a major depressive episode With Major Depressive-Like episode: if the full criteria are met ( Expect criterion D) for a major depressive episode With Manic features: if the predominant mood is elevated, euphoric, or irritable With mixed features: if the sx of both mania and depression are present but neither predominates
Multi-axial system
The DSM-IV organizes each psychiatric diagnosis into five levels (axes) relating to different aspects of disorder or disability: Axis I: clinical disorders, including major mental disorders, as well as developmental and learning disorders Axis II: underlying pervasive or personality conditions, as well as mental retardation Axis III: Acute medical conditions and physical disorders. Axis IV: psychosocial and environmental factors contributing to the disorder Axis V: Global Assessment of Functioning or Childrens Global Assessment Scale for children under the age of 18. (on a scale from 100 to 0)
Self-concept
Sense of self-esteem is greatly reduced Uses phrases such as good for nothing or just worthless to describe themselves Feels guilty about not being able to function Personalize events or take responsibility for incidents over which they have no control Believe that others would be better of without them, which leads to suicide thoughts
Data Analysis:
Common Nsg Dx:
Risk for suicide Imbalanced Nutrition: Less Than Body Requirements Anxiety Ineffective Coping Hopelessness Ineffective Role Performance Self Care Deficit Chronic Low Self Esteem Disturbed Sleep Pattern Impaired Social Interaction
Outcome Identification:
Examples:
The client will: Not injure himslef or herself Independently carry out ADLs Establish a balance of rest, sleep and activity Establish a balance of adequate nutrition, hydration, and elimination Evaluate self attributes realistically Socialize with staff, peers, family, and friends Return to occupation or school activities Comply with antidepressant regimen Verbalize symptoms of a recurrence
Intervention:
Ex: Provide for safety of the client and others Institute suicide precaution if indicated Begin a therapeutic relationship by spending nondemanding time with the client Promote completion of ADLs by assisting the client only when necessary Establish adequate nutrition and hydration Promote rest and sleep Engage the client in activities Encourage the client to verbalize and describe emotions Work with the client to manage medications and side effects
Evaluation:
It is essential that the client feel safe and are not experiencing uncontrollable urges to commit suicide Participation in therapy and medication compliance produces more favorable outcomes for clients with depression Be able to identify signs of relapse and seek treatment immediately can significantly decrease the severity of a depressive episode.
Self-concept
Exaggerated self-esteembelieves they can accomplish anything Rarely discuss their self-concept realistically A false sense of well being masks difficulties with chronic low self-esteem
Data Analysis:
Common Nsg Dx:
Risk for Other-Directed Violence Risk for Injury Imbalanced Nutrition: Less Than Body Requirements Ineffective Coping Noncompliance Hopelessness Ineffective Role Performance Self Care Deficit Chronic Low Self Esteem Disturbed Sleep Pattern
Outcome Identification:
Examples:
The client will: Not injure himself or herself Independently carry out ADLs Establish a balance of rest, sleep and activity Establish a balance of adequate nutrition, hydration, and elimination Participate in self-care activities Engage in socially appropriate, reality-based interaction Evaluate self attributes realistically Verbalize knowledge of his or her illness or treatment
Intervention:
Provide for clients physical safely and safety of those around the client. Set limits on clients behavior when needed Remind the client to respect distances between self and others Use short, simple sentences to communicate Clarify the meaning of clients communication Frequently provide finger foods that are high in calories and protein Promote rest and sleep Promote the clients dignity when inappropriate behavior occurs Channel clients need for movement into socially acceptable motor activities Manage medication regimen Provide client and family teaching
Evaluation:
The evaluation of the tx for Bipolar Disorder includes but is not limited to the FF: Safety issues Comparison of mood and affect between start of treatment and present Adherence to treatment regimen of medication and psychotherapy Changes in clients perception of quality of life Achievement of specific goals of treatment including new coping methods
Treatment Modalities:
Top Rated Choices for Initial Medications
Euphoric mania or hypomania Mixed or dysphoric mania Mania with psychosis Lithium or divalproex Divalproex Divalproex or Lithium w/ antipsychotic (atypical or conventional)
Commonly Used mood stabilizers, usual Adult doses and therapeutic serum levels
Mood Stabilizer
Lithium (Eskalith, Lithobid, Lithonate) Divalproex (Depakote)
Other anticonvulsants used as mood stabilizers
750-4200mg/d
50-100u/ml
400-1600mg/d
300-500mg/dl 400-1600mg/d
412u/ml
N/A
End of concept